{"type":"trials","record":{"id":44288,"source_id":"clinicaltrials-gov","external_id":"NCT04194866","title":"The Effect of Circadian Clock System on Perioperative Cognitive Function of Elderly Patients","brief_summary":"Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and above. It refers to the cognitive function changes such as memory decline and attention loss after anesthesia and surgery. In serious cases, people may also experience personality changes and decline in social behavior ability, which will develop into irreversible cognitive impairment.Some studies reported that 25.8% of elderly patients presented POCD one week after non-cardiac surgery, and the incidence at 3 months after surgery was still 9.9%, which could increase the mortality in the first year after surgery.In recent years, studies have also proved that POCD is associated with patients' inability to perform their original jobs after non-cardiac surgery.Postoperative cognitive dysfunction seriously affects the clinical outcome, in addition to medical costs and other issues will bring an impact on the society and family.With the aging of the population, how to prevent cognitive dysfunction in elderly patients is a major challenge for perioperative management.There is a certain correlation between circadian rhythm and the dosage of general anesthesia, and postoperative sleep disturbance may be related to the effect of anesthesia and surgery on circadian rhythm.Preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD), but the circadian mechanisms involved after general anesthesia are not yet clear","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Shengjing Hospital","enrollment":120,"countries":["China"],"start_date":"2020-01-01","completion_date":"2022-12-31","last_update_date":"2019-12-11","source_url":"https://clinicaltrials.gov/study/NCT04194866","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:48.846222+00:00","last_seen_at":"2026-09-25T06:25:39.067+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 90 Years","comparator":null,"organization":"Shengjing Hospital","interventions":["receiving operation during the day or at night"],"registry_source":"ClinicalTrials.gov","outcome_measures":["postoperative sleep quality of one night before surgery — one night before the surgery","postoperative sleep quality of first night after surgery — the first night after surgery","postoperative sleep quality of third night after surgery — the third night after surgery","Preoperative cognitive function test — one day before surgery","Postoperative cognitive function test of 6 weeks after surgery — 6 weeks after surgery","Postoperative cognitive function test of 1 year after surgery — 1 year after surgery","Postoperative cognitive function test of 3 years after surgery — 3 years after surgery"],"design_description":"RANDOMIZED · PARALLEL · OTHER · QUADRUPLE","source_has_results":false},"controlled_terms":["Circadian Clock","Postoperative Cognitive Function","General Anesthesia","Elderly Patients","receiving operation during the day or at night"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: circadian clock.","quality_checked_at":"2026-09-25T06:25:42.287439+00:00","duplicate_cluster_key":"id:nct04194866","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-01-01 to 2022-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:39.114Z","intervention":["receiving operation during the day or at night"],"participants":120,"study_design":"RANDOMIZED · PARALLEL · OTHER · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["postoperative sleep quality of one night before surgery — one night before the surgery","postoperative sleep quality of first night after surgery — the first night after surgery","postoperative sleep quality of third night after surgery — the third night after surgery","Preoperative cognitive function test — one day before surgery","Postoperative cognitive function test of 6 weeks after surgery — 6 weeks after surgery","Postoperative cognitive function test of 1 year after surgery — 1 year after surgery","Postoperative cognitive function test of 3 years after surgery — 3 years after surgery"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"circadian-rhythms","is_published":true,"match_reasons":["Title contains controlled term: circadian clock.","Abstract contains controlled term: circadian rhythm.","Source terminology contains: circadian clock.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Circadian rhythms","slug":"circadian-rhythms"}},{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: circadian.","Abstract contains controlled term: sleep, circadian.","Source terminology contains: circadian.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/44288","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}