{"type":"trials","record":{"id":45038,"source_id":"clinicaltrials-gov","external_id":"NCT06951620","title":"Optimizing Aerobic Fitness in Older Adults","brief_summary":"Hospitalization and treatment for cardiovascular disease is one of the main contributors to disability in older adults. Moderate intensity continuous aerobic and resistance training have been the cornerstone of cardiac rehabilitation (CR) for decades to remediate hospital-acquired functional deficits, but some groups receive less or minimal functional benefit from this training. The proposed studies seek to optimize recovery of aerobic fitness and physical function among older cardiac patients using a novel high intensity training regimen with the long-term goal of reducing subsequent disability and improving clinical outcomes.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Vermont Medical Center","enrollment":114,"countries":["United States"],"start_date":"2025-04-17","completion_date":"2029-06-30","last_update_date":"2025-06-08","source_url":"https://clinicaltrials.gov/study/NCT06951620","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:30:14.100152+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"University of Vermont Medical Center","interventions":["HIIT","MICT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Aerobic fitness — Within 4 months of the intake assessment","Change in 30 sec sit-to-stand test (STS) — Within 4 months of the intake assessment","Changes in Quality of Life- Cardiac Specific — Within 4 months of the intake assessment","Changes in Depressive Symptoms — Within 4 months of the intake assessment","Changes in Executive Function (digit span) — Within 4 months of the intake assessment","Changes in Executive Function (BRIEF) — Within 4 months of the intake assessment","Changes in Executive Function (trail making) — Within 4 months of the intake assessment","Changes in Physical Function (Six Minute Walk Test) — Within 4 months of the intake assessment","Changes in Enjoyment of Exercise (PACES) — Within 4 months of the intake assessment","Changes in Anxiety — Within 4 months of the intake assessment"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Aerobic Capacity","High Intensity Interval Training","HIIT","MICT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: aerobic fitness.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct06951620","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-17 to 2029-06-30","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.302Z","intervention":["HIIT","MICT"],"participants":114,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Aerobic fitness — Within 4 months of the intake assessment","Change in 30 sec sit-to-stand test (STS) — Within 4 months of the intake assessment","Changes in Quality of Life- Cardiac Specific — Within 4 months of the intake assessment","Changes in Depressive Symptoms — Within 4 months of the intake assessment","Changes in Executive Function (digit span) — Within 4 months of the intake assessment","Changes in Executive Function (BRIEF) — Within 4 months of the intake assessment","Changes in Executive Function (trail making) — Within 4 months of the intake assessment","Changes in Physical Function (Six Minute Walk Test) — Within 4 months of the intake assessment","Changes in Enjoyment of Exercise (PACES) — Within 4 months of the intake assessment","Changes in Anxiety — Within 4 months of the intake assessment"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"aerobic-fitness","is_published":true,"match_reasons":["Title contains controlled term: aerobic fitness.","Abstract contains controlled term: aerobic fitness.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Aerobic fitness and VO2 max","slug":"aerobic-fitness"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/45038","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}