{"type":"trials","record":{"id":45446,"source_id":"clinicaltrials-gov","external_id":"NCT03282682","title":"Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male","brief_summary":"This study examines the effect of 12-week strength training program with and without testosterone replacement therapy (TRT) on body composition, physical function, selected biochemical markers of metabolic health, molecular parameters of training adaptation and the quality of life patients with ADAM. The investigators believe, that strength training program performed 2 times per week for 12 weeks can improve body composition (decrease fat mass and gain lean mass), muscle strength, muscle power and general quality of life in all training groups. In addition, combination TRT and strength training could help decrease fat mass, improve BMI, cardio-respiratory fitness and thus provide optimal therapy combination for hypogonadal ageing males.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Comenius University","enrollment":22,"countries":["Slovakia"],"start_date":"2017-10-01","completion_date":"2019-05-30","last_update_date":"2021-07-30","source_url":"https://clinicaltrials.gov/study/NCT03282682","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:30:14.100152+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"MALE","acronym":null,"age_range":"45 Years to 60 Years","comparator":"healthy eugonadal males","organization":"Comenius University","interventions":["Strength training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change From Baseline in Lean Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in Fat Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in Total Body Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in 10-m Usual Walk Test — 7 days before intervention, 7 days after intervention","Change From Baseline in 10-m Fast Walk Test — 7 days before intervention, 7 days after intervention","Change From Baseline in Handgrip Strength — 7 days before intervention, 7 days after intervention","Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Extension — 7 days before intervention, 7…","Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Flexion — 7 days before intervention, 7 d…","Change From Baseline in The Single Stage Treadmill Walking Test — 7 days before intervention, 7 days after intervention","Change From Baseline in Predicted One Repetition Maximum on Leg Press — 7 days before intervention, 7 days after interv…","Change From Baseline in Maximal Voluntary Contraction in Benchpress — 7 days before intervention, 7 days after interven…","Change From Baseline in The Short Form Health Survey (SF-36) — 7 days before intervention, 7 days after intervention","Change From Baseline in Aging Males' Symptom (AMS) Scale — 7 days before intervention, 7 days after intervention","Change From Baseline in Metabolic Parameters — 7 days before intervention, 7 days after intervention","Change From Baseline in Liver Function Blood Parameters — 7 days before intervention, 14 days after intervention","Change From Baseline in Hormonal Parameters — 7 days before intervention, 14 days after intervention","Change From Baseline in Ions — 7 days before intervention, 14 days after intervention","Change From Baseline in CRP — 7 days before intervention, 14 days after intervention","Change From Baseline in Muscle Fiber Size — 7 days before intervention, 14 days after intervention","Change From Baseline in Regulators of Muscle Fiber Size — 7 days before intervention, 14 days after intervention"],"design_description":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":true},"controlled_terms":["Hypogonadism, Male","Physical Activity","Testosterone Deficiency","Strength training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct03282682","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-10-01 to 2019-05-30","comparator":"healthy eugonadal males","confidence":"structured-source","population":"MALE · 45 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.338Z","intervention":["Strength training"],"participants":22,"study_design":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change From Baseline in Lean Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in Fat Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in Total Body Mass — 7 days before intervention, 7 days after intervention","Change From Baseline in 10-m Usual Walk Test — 7 days before intervention, 7 days after intervention","Change From Baseline in 10-m Fast Walk Test — 7 days before intervention, 7 days after intervention","Change From Baseline in Handgrip Strength — 7 days before intervention, 7 days after intervention","Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Extension — 7 days before intervention, 7…","Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Flexion — 7 days before intervention, 7 d…","Change From Baseline in The Single Stage Treadmill Walking Test — 7 days before intervention, 7 days after intervention","Change From Baseline in Predicted One Repetition Maximum on Leg Press — 7 days before intervention, 7 days after interv…","Change From Baseline in Maximal Voluntary Contraction in Benchpress — 7 days before intervention, 7 days after interven…","Change From Baseline in The Short Form Health Survey (SF-36) — 7 days before intervention, 7 days after intervention","Change From Baseline in Aging Males' Symptom (AMS) Scale — 7 days before intervention, 7 days after intervention","Change From Baseline in Metabolic Parameters — 7 days before intervention, 7 days after intervention","Change From Baseline in Liver Function Blood Parameters — 7 days before intervention, 14 days after intervention","Change From Baseline in Hormonal Parameters — 7 days before intervention, 14 days after intervention","Change From Baseline in Ions — 7 days before intervention, 14 days after intervention","Change From Baseline in CRP — 7 days before intervention, 14 days after intervention","Change From Baseline in Muscle Fiber Size — 7 days before intervention, 14 days after intervention","Change From Baseline in Regulators of Muscle Fiber Size — 7 days before intervention, 14 days after intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/45446","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}