{"type":"trials","record":{"id":45758,"source_id":"clinicaltrials-gov","external_id":"NCT07443189","title":"Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.","brief_summary":"This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function. The randomized intervention component tests whether improving fitness via a home-based HIIT program leads to changes in fitness and related cognitive/language outcomes in older adults.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Agder","enrollment":233,"countries":["Norway","United Kingdom"],"start_date":"2021-09-01","completion_date":"2023-11-30","last_update_date":"2026-03-02","source_url":"https://clinicaltrials.gov/study/NCT07443189","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:30:18.816162+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"FAB","age_range":"60 Years to 85 Years","comparator":"Control group","organization":"University of Agder","interventions":["Home-Based HIIT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Aerobic fitness - VO₂peak — Baseline; 26 weeks (post-intervention)","Language function - Tip-of-the-tongue (TOT) task — Baseline; 26 weeks (post-intervention)","Language function - sentence production (speeded picture description) — Baseline; 26 weeks (post-intervention)","Language function - sentence comprehension (auditory word monitoring) — Baseline; 26 weeks (post-intervention)","Language function - discourse production (free picture description) — Baseline; 26 weeks (post-intervention)","Language control - language switching (bilinguals only; cued picture naming) — Baseline; 26 weeks (post-intervention)","Cognitive function - processing speed (letter comparison) — Baseline; 26 weeks (post-intervention)","Cognitive function - working memory (n-back) — Baseline; 26 weeks (post-intervention)","Cognitive function - working memory (digit span) — Baseline; 26 weeks (post-intervention)","Cognitive function - attention/executive control (Attention Network Task; ANT) — Baseline; 26 weeks (post-intervention)","Cognitive function - task switching (colour-shape switching) — Baseline; 26 weeks (post-intervention)","Aerobic fitness - blood lactate concentration — Baseline; 26 weeks (post-intervention)","Physical function - handgrip strength — Baseline; 26 weeks (post-intervention)","Physical function - 30-second chair stand — Baseline; 26 weeks (post-intervention)","Physical function - chair sit-and-reach (hamstring flexibility) — Baseline; 26 weeks (post-intervention)","Physical function - back scratch (shoulder flexibility) — Baseline; 26 weeks (post-intervention)","Physical function - 8-foot up-and-go (mobility/agility) — Baseline; 26 weeks (post-intervention)","Physical function - one-leg standing balance (OLSB) — Baseline; 26 weeks (post-intervention)","MRI - structural T1-weighted imaging — Baseline; 26 weeks (post-intervention)","MRI - task fMRI — Baseline; 26 weeks (post-intervention)"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Healthy Ageing","Cognitive Decline","Cardiorespiratory Fitness","Home-Based HIIT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07443189","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-09-01 to 2023-11-30","comparator":"Control group","confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.283Z","intervention":["Home-Based HIIT"],"participants":233,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Aerobic fitness - VO₂peak — Baseline; 26 weeks (post-intervention)","Language function - Tip-of-the-tongue (TOT) task — Baseline; 26 weeks (post-intervention)","Language function - sentence production (speeded picture description) — Baseline; 26 weeks (post-intervention)","Language function - sentence comprehension (auditory word monitoring) — Baseline; 26 weeks (post-intervention)","Language function - discourse production (free picture description) — Baseline; 26 weeks (post-intervention)","Language control - language switching (bilinguals only; cued picture naming) — Baseline; 26 weeks (post-intervention)","Cognitive function - processing speed (letter comparison) — Baseline; 26 weeks (post-intervention)","Cognitive function - working memory (n-back) — Baseline; 26 weeks (post-intervention)","Cognitive function - working memory (digit span) — Baseline; 26 weeks (post-intervention)","Cognitive function - attention/executive control (Attention Network Task; ANT) — Baseline; 26 weeks (post-intervention)","Cognitive function - task switching (colour-shape switching) — Baseline; 26 weeks (post-intervention)","Aerobic fitness - blood lactate concentration — Baseline; 26 weeks (post-intervention)","Physical function - handgrip strength — Baseline; 26 weeks (post-intervention)","Physical function - 30-second chair stand — Baseline; 26 weeks (post-intervention)","Physical function - chair sit-and-reach (hamstring flexibility) — Baseline; 26 weeks (post-intervention)","Physical function - back scratch (shoulder flexibility) — Baseline; 26 weeks (post-intervention)","Physical function - 8-foot up-and-go (mobility/agility) — Baseline; 26 weeks (post-intervention)","Physical function - one-leg standing balance (OLSB) — Baseline; 26 weeks (post-intervention)","MRI - structural T1-weighted imaging — Baseline; 26 weeks (post-intervention)","MRI - task fMRI — Baseline; 26 weeks (post-intervention)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: physical activity.","Source terminology contains: cardiorespiratory fitness.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/45758","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}