{"type":"trials","record":{"id":467,"source_id":"clinicaltrials-gov","external_id":"NCT06866184","title":"Regenerative Effects of Birth Material Derived Extracellular Vesicles","brief_summary":"Stem cells offer great hope for a wide range of disorders, including age-related brain disease such as dementia. Mesenchymal stem cells (MSCs) are special types of adult stem cells found in various tissues like the umbilical cord, placenta and bone marrow. These cells can develop into different cell types, such as bone, cartilage, muscle, and neurones. They can promote healing, regulate the immune system and repair damaged tissues. Extracellular vesicles (EVs) are tiny, bubble-like structures released by MSCs, which help communication between tissues and organs by delivering specific instructions and regenerative substances. Therefore, MSC-EVs are thought to be responsible for many of beneficial effects. Recent evidence suggests that specific properties of EVs depend on where the MSCs come from, how old the donor was, and the environment/conditions they are in. To better understand the…","overall_status":"Suspended","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Aberdeen","enrollment":60,"countries":["United Kingdom"],"start_date":"2026-10-01","completion_date":"2028-01-01","last_update_date":"2026-05-26","source_url":"https://clinicaltrials.gov/study/NCT06866184","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Suspended. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:04.929625+00:00","last_seen_at":"2026-09-15T00:18:36.032+00:00","metadata":{"acronym":"ReGAIN","organization":"University of Aberdeen","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct06866184","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/467","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}