{"type":"trials","record":{"id":47,"source_id":"clinicaltrials-gov","external_id":"NCT07429955","title":"Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults","brief_summary":"This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday independence in people aged 75 years or older. About 20 volunteers, scheduled for surgery because of a recent femoral-neck fracture or severe arthritis that no longer responds to usual care, will give consent, answer brief health questionnaires, attempt simple walking and chair-rise tests if possible, and provide a small blood sample. While they are already under anaesthesia for their planned operation, the surgical team will take a tiny muscle sample through the same incision, so no extra cuts are needed. During the hospital stay or shortly after discharge, each participant will have a painless MRI scan of the thigh muscles and a very-low-dose bone scan (DXA) to measure muscle and bone health. The research team will then telephone participants at 3 and 6 months to ask about daily activities, walking ability, and any complications. The study lasts about six months for each person and does not alter their usual medical or rehabilitation care. Potential benefits include close follow-up, personalised feedback on muscle and bone results, and helping doctors learn whether pre-surgery muscle weakness predicts slower recovery-information that could guide future, more personalised exercise and nutrition programs. Extra study procedures carry only minimal risks: a routine blood draw, scans with none (MRI) or very little (DXA) radiation, and a muscle biopsy taken during surgery. Taking part is entirely voluntary, and participants may withdraw at any time without affecting their current or future care. The whole project will run for 18 months.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University Hospital, Montpellier","enrollment":20,"countries":["France"],"start_date":"2026-08-17","completion_date":"2028-08-17","last_update_date":"2026-09-10","source_url":"https://clinicaltrials.gov/study/NCT07429955","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:59.105435+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"HIP-REGEN","age_range":"75 Years","comparator":null,"organization":"University Hospital, Montpellier","interventions":["Total hip replacement","Blood sampling","Muscle biopsies","Collection of joint samples derived from surgical waste","DXA","MRI","Handgrip strength test"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from Baseline in the Barthel Index at 3 months post-operative — Baseline and 3 months","Change from Baseline in the Barthel Index at 6 months post-operative — Baseline and 6 months","Measurement of hand-grip strength via dynamometry — Baseline","Measurement of appendicular lean mass by DXA — Prior to surgery or within 7 days postoperatively","Measurement of quadriceps mass by MRI — Prior to surgery or within 7 days postoperatively","Number of myoblastic progenitors at proliferation onset — Intraoperative","Mean myotube surface area at differentiation end — Intraoperative","Proportion of senescent MSCs — Intraoperative","Number of chondrocytes obtained from MSCs at differentiation end — Intraoperative","Number of adipocytes obtained from MSCs at differentiation end — Intraoperative","Number of osteocytes obtained from MSCs at differentiation end. — Intraoperative","Serum concentation of myostatin — Baseline and 3 month","Serum concentation of myostatin — Baseline and 6 month","Serum concentation of follistatin — Baseline and 3 month","Serum concentation of follistatin — Baseline and 6 month","Serum concentation of irisin — Baseline and 3 month","Serum concentation of irisin — Baseline and 6 month","Serum concentation of IL-6 — Baseline and 3 month","Serum concentation of IL-6 — Baseline and 6 month","Serum concentation of IGF-1 — Baseline and 3 month"],"design_description":"NA · SINGLE GROUP · SCREENING · NONE","source_has_results":false},"controlled_terms":["Sarcopenia in Elderly","Osteoarthritis (OA)","Hip Fracture Surgeries","Total hip replacement","Blood sampling","Muscle biopsies","Collection of joint samples derived from surgical waste","DXA","MRI","Handgrip strength test"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07429955","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-08-17 to 2028-08-17","comparator":null,"confidence":"structured-source","population":"ALL · 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.754Z","intervention":["Total hip replacement","Blood sampling","Muscle biopsies","Collection of joint samples derived from surgical waste","DXA","MRI","Handgrip strength test"],"participants":20,"study_design":"NA · SINGLE GROUP · SCREENING · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from Baseline in the Barthel Index at 3 months post-operative — Baseline and 3 months","Change from Baseline in the Barthel Index at 6 months post-operative — Baseline and 6 months","Measurement of hand-grip strength via dynamometry — Baseline","Measurement of appendicular lean mass by DXA — Prior to surgery or within 7 days postoperatively","Measurement of quadriceps mass by MRI — Prior to surgery or within 7 days postoperatively","Number of myoblastic progenitors at proliferation onset — Intraoperative","Mean myotube surface area at differentiation end — Intraoperative","Proportion of senescent MSCs — Intraoperative","Number of chondrocytes obtained from MSCs at differentiation end — Intraoperative","Number of adipocytes obtained from MSCs at differentiation end — Intraoperative","Number of osteocytes obtained from MSCs at differentiation end. — Intraoperative","Serum concentation of myostatin — Baseline and 3 month","Serum concentation of myostatin — Baseline and 6 month","Serum concentation of follistatin — Baseline and 3 month","Serum concentation of follistatin — Baseline and 6 month","Serum concentation of irisin — Baseline and 3 month","Serum concentation of irisin — Baseline and 6 month","Serum concentation of IL-6 — Baseline and 3 month","Serum concentation of IL-6 — Baseline and 6 month","Serum concentation of IGF-1 — Baseline and 3 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/47","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}