{"type":"trials","record":{"id":474,"source_id":"clinicaltrials-gov","external_id":"NCT06748586","title":"The Effect of Hyperbaric Oxygen Therapy on Circulating Hematopoietic Stem Cell Population","brief_summary":"Hematopoietic stem cells (HSCs), which govern the production of all blood lineages, transition through a series of functional states characterized by expansion during fetal development, functional quiescence in adulthood, and decline upon aging. Although research on aging has for a long time been relatively descriptive, much progress has been made in the past decade to uncover the molecular drivers of biological aging. One such drivers relates to stem cell exhaustion. The amount and the function of HSCs decline in humans along aging. This decline is characterized by different changes such as signaling, epigenetic, cell surface markers etc. Various studies have been conducted to identify HSCs surface markers using flow cytometry. Exposure to Hyperbaric Oxygen Therapy (HBOT) induce stem cells proliferation mobilization of stem progenitor cells (SPCs) in both animal and humans studies, and…","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Assaf-Harofeh Medical Center","enrollment":60,"countries":["Israel"],"start_date":"2025-03-05","completion_date":"2027-12-30","last_update_date":"2026-04-21","source_url":"https://clinicaltrials.gov/study/NCT06748586","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:04.929625+00:00","last_seen_at":"2026-09-15T00:18:36.032+00:00","metadata":{"acronym":null,"organization":"Assaf-Harofeh Medical Center","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct06748586","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/474","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}