{"type":"trials","record":{"id":503,"source_id":"clinicaltrials-gov","external_id":"NCT07705178","title":"More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)","brief_summary":"In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Erlangen-Nürnberg Medical School","enrollment":180,"countries":["Germany"],"start_date":"2026-07-14","completion_date":"2028-10-31","last_update_date":"2026-07-15","source_url":"https://clinicaltrials.gov/study/NCT07705178","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:05.518263+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"MaximALL","age_range":"3 Years","comparator":null,"organization":"University of Erlangen-Nürnberg Medical School","interventions":["QOL assessment, Neuropsychological","Spirometry","DLCO measurement","Echocardioraphy","MRI","Clinical parameters","Blood samples","MSOT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Morphological lung changes (MRI) — Single time point","Functional lung parameters (MRI) — Single time point","Quantitative and functional cardiovascular changes (MRI) — Single time point","DLCO — Single time point","VA — Single time point","KCO — Single time point","VC — single time point","FEV1 — Single time point","VO2 — Single time point","VO2max — Single time point","RER — Single time point","VT2 — Single time point","VCO2 — Single time point","HR — Single time point","HRR — Single time point","Breath rate at VAT — Single time point","BRR — Single time point","VE — Single time point","O2 Pulse — Single time point","HRV — Single time point"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Acute Lymphatic Leukemia","Lymphoma","QOL assessment, Neuropsychological","Spirometry","DLCO measurement","Echocardioraphy","MRI","Clinical parameters","Blood samples","MSOT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: cancer.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07705178","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-07-14 to 2028-10-31","comparator":null,"confidence":"structured-source","population":"ALL · 3 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.263Z","intervention":["QOL assessment, Neuropsychological","Spirometry","DLCO measurement","Echocardioraphy","MRI","Clinical parameters","Blood samples","MSOT"],"participants":180,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Morphological lung changes (MRI) — Single time point","Functional lung parameters (MRI) — Single time point","Quantitative and functional cardiovascular changes (MRI) — Single time point","DLCO — Single time point","VA — Single time point","KCO — Single time point","VC — single time point","FEV1 — Single time point","VO2 — Single time point","VO2max — Single time point","RER — Single time point","VT2 — Single time point","VCO2 — Single time point","HR — Single time point","HRR — Single time point","Breath rate at VAT — Single time point","BRR — Single time point","VE — Single time point","O2 Pulse — Single time point","HRV — Single time point"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cancer-and-aging","is_published":true,"match_reasons":["Title contains controlled term: cancer.","Abstract contains controlled term: cancer.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cancer and ageing","slug":"cancer-and-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/503","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}