{"type":"trials","record":{"id":50682,"source_id":"clinicaltrials-gov","external_id":"NCT06501066","title":"Mesenchymal Stem Cells for Frailty Syndrome","brief_summary":"This Phase I/II study is designed to evaluate the efficacy and safety of UMC119-06-05, an allogeneic umbilical cord mesenchymal stem cells, in older adults with frailty syndrome. This study will also seek to determine the long-term safety and clinical outcomes of UMC119-06-05 in subjects with frailty syndrome, which will provide information for subsequent clinical trials with UMC119-06-05.","overall_status":"Active Not Recruiting","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Meribank Biotech Co., Ltd.","enrollment":66,"countries":["Taiwan"],"start_date":"2024-06-03","completion_date":"2027-12-01","last_update_date":"2024-07-15","source_url":"https://clinicaltrials.gov/study/NCT06501066","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:40:48.95077+00:00","last_seen_at":"2026-09-25T06:05:08.502+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Phase II Placebo Arm","organization":"Meribank Biotech Co., Ltd.","interventions":["umbilical cord mesenchymal stem cells"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence of Treatment-Emergent Adverse Events (TEAEs)/ Serious Adverse Events (SAEs). — Up to 12 months through study","Incidence of withdrawals due to adverse events — Up to 12 months through study","vital signs — Up to 12 months through study","physical examination — Up to 12 months through study","clinical laboratory test results — Up to 12 months through study","electrocardiogram — Up to 12 months through study","Mean change from baseline in frailty status (Cardiovascular Health Study [CHS] frailty score — change from baseline to…","Mean change from baseline in grip strength — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in chair-stand test — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in muscle mass and bone density — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in quality of life measured by change in SF-12 — change from baseline to Day 91, Day 181, and…"],"design_description":"RANDOMIZED · SEQUENTIAL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Pathologic Processes","umbilical cord mesenchymal stem cells"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:05:13.559725+00:00","duplicate_cluster_key":"id:nct06501066","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-06-03 to 2027-12-01","comparator":"Phase II Placebo Arm","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:08.527Z","intervention":["umbilical cord mesenchymal stem cells"],"participants":66,"study_design":"RANDOMIZED · SEQUENTIAL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence of Treatment-Emergent Adverse Events (TEAEs)/ Serious Adverse Events (SAEs). — Up to 12 months through study","Incidence of withdrawals due to adverse events — Up to 12 months through study","vital signs — Up to 12 months through study","physical examination — Up to 12 months through study","clinical laboratory test results — Up to 12 months through study","electrocardiogram — Up to 12 months through study","Mean change from baseline in frailty status (Cardiovascular Health Study [CHS] frailty score — change from baseline to…","Mean change from baseline in grip strength — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in chair-stand test — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in muscle mass and bone density — change from baseline to Day 91, Day 181, and Day 361","Mean change from baseline in quality of life measured by change in SF-12 — change from baseline to Day 91, Day 181, and…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Source terminology contains: stem cell.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/50682","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}