{"type":"trials","record":{"id":507,"source_id":"clinicaltrials-gov","external_id":"NCT04975815","title":"Frailty and Dysphagia in Older Adults","brief_summary":"The purpose of this research study is to figure out if there are physical factors such as cognition level, nutrition status, walking speed, and handgrip strength that are associated with the development of swallowing problems. Investigators want to better understand how swallowing problems develop in older adults with and without frailty. Identifying factors that contribute to swallowing problems, can develop therapies in the future to improve swallowing outcomes for older adults. This study will be done at the University of Wisconsin-Madison (UW-Madison). A total of about 69 people will participate in this study.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Wisconsin, Madison","enrollment":52,"countries":["United States"],"start_date":"2022-04-06","completion_date":"2025-03-14","last_update_date":"2026-07-09","source_url":"https://clinicaltrials.gov/study/NCT04975815","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:05.518263+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"University of Wisconsin, Madison","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Score on Modified Barium Swallow Impairment Profile (MBSImP) — 2 weeks","Number of participants with presence/absence of dysphagia based on Dynamic Imaging Grade of Swallowing Toxicity (DIGEST…","Score on Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scale: Dysphagia severity — 2 weeks","Swallowing reaction time (ms) — 2 weeks","Hyoid burst to upper esophageal sphincter open (ms) — 2 weeks","Upper esophageal sphincter opening duration (ms) — 2 weeks","Laryngeal closure reaction time (ms) — 2 weeks","Laryngeal closure duration (ms). — 2 weeks","Extent of hyoid movement (mm) — 2 weeks","Upper esophageal sphincter (UES) opening width (mm) — 2 weeks","Pixel-based measure of pharyngeal residue (%C2-C4 squared) — 2 weeks","Pharyngeal constriction ratio (PCR) — 2 weeks","Masticatory efficiency evaluated by Test of Masticating and Swallowing Solids (TOMASS) — 2 weeks","Number of participants assessed as pass/fail the three ounce water swallow test — 2 weeks","Pharyngeal Pressure Outcome: Integral pressure (mmHg*time) — 2 weeks","Pharyngeal Pressure Outcome: Pharyngeal contractile integral (PhCI) — 2 weeks","Pharyngeal Pressure Outcome: Total swallow duration — 2 weeks","Lingual Pressure Outcome: Mean slope (kpa/seconds) — Day 0","Lingual Pressure Outcome: Maximum lingual pressure — Day 0","Lingual Pressure Outcome: Saliva swallow pressure — Day 0"],"design_description":null,"source_has_results":false},"controlled_terms":["Dysphagia","Frailty"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct04975815","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-04-06 to 2025-03-14","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.412Z","intervention":[],"participants":52,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Score on Modified Barium Swallow Impairment Profile (MBSImP) — 2 weeks","Number of participants with presence/absence of dysphagia based on Dynamic Imaging Grade of Swallowing Toxicity (DIGEST…","Score on Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scale: Dysphagia severity — 2 weeks","Swallowing reaction time (ms) — 2 weeks","Hyoid burst to upper esophageal sphincter open (ms) — 2 weeks","Upper esophageal sphincter opening duration (ms) — 2 weeks","Laryngeal closure reaction time (ms) — 2 weeks","Laryngeal closure duration (ms). — 2 weeks","Extent of hyoid movement (mm) — 2 weeks","Upper esophageal sphincter (UES) opening width (mm) — 2 weeks","Pixel-based measure of pharyngeal residue (%C2-C4 squared) — 2 weeks","Pharyngeal constriction ratio (PCR) — 2 weeks","Masticatory efficiency evaluated by Test of Masticating and Swallowing Solids (TOMASS) — 2 weeks","Number of participants assessed as pass/fail the three ounce water swallow test — 2 weeks","Pharyngeal Pressure Outcome: Integral pressure (mmHg*time) — 2 weeks","Pharyngeal Pressure Outcome: Pharyngeal contractile integral (PhCI) — 2 weeks","Pharyngeal Pressure Outcome: Total swallow duration — 2 weeks","Lingual Pressure Outcome: Mean slope (kpa/seconds) — Day 0","Lingual Pressure Outcome: Maximum lingual pressure — Day 0","Lingual Pressure Outcome: Saliva swallow pressure — Day 0"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/507","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}