{"type":"trials","record":{"id":5449,"source_id":"clinicaltrials-gov","external_id":"NCT07531498","title":"Muscle Aging Phenotypes in Childhood Cancer Survivors","brief_summary":"Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distinct muscle health endotypes in adult survivors of childhood cancer using advanced imaging, neuromuscular testing, and functional assessment. Survivors with reduced muscle health and community controls will undergo multimodal magnetic resonance imaging and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing during a single study visit integrated into an ongoing cohort evaluation. Identifying mechanistic endotypes of impaired muscle health will support development of targeted interventions to preserve function and improve long-term outcomes in childhood cancer survivors. Primary Objective: \\- Characterize reduced muscle health endotypes in childhood cancer survivors. Secondary Objective: \\- Identify specific treatment and lifestyle related risk factors for each reduced muscle health endotype. Exploratory Objective: \\- Host germline genetics will be associated with specific muscle endotypes.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"St. Jude Children's Research Hospital","enrollment":533,"countries":["United States"],"start_date":"2026-09-14","completion_date":"2031-05-01","last_update_date":"2026-09-16","source_url":"https://clinicaltrials.gov/study/NCT07531498","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-16T12:17:06.74576+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"St. Jude Children's Research Hospital","interventions":["Multimodal Muscle Imaging and Functional Assessment","Multimodal Muscle Imaging and Neuromuscular Assessment","Comprehensive Muscle Phenotyping","Integrated Neuromuscular and Imaging Evaluation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Nerve conduction velocity (NCV) at rest and Electromyography (EMG) during submaximal and maximal force generation — Bas…","Creatinine recovery post exercise with magnetic resonance imaging (MRI) — Baseline","Intramyocellular and extramyocellular fat fraction in muscle during magnetic resonance imaging (MRI) and magnetic reson…"],"design_description":null,"source_has_results":false},"controlled_terms":["Muscle Weakness","Low Muscle Mass","Sarcopenia","Multimodal Muscle Imaging and Functional Assessment","Multimodal Muscle Imaging and Neuromuscular Assessment","Comprehensive Muscle Phenotyping","Integrated Neuromuscular and Imaging Evaluation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: muscle aging.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07531498","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-09-14 to 2031-05-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.751Z","intervention":["Multimodal Muscle Imaging and Functional Assessment","Multimodal Muscle Imaging and Neuromuscular Assessment","Comprehensive Muscle Phenotyping","Integrated Neuromuscular and Imaging Evaluation"],"participants":533,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Nerve conduction velocity (NCV) at rest and Electromyography (EMG) during submaximal and maximal force generation — Bas…","Creatinine recovery post exercise with magnetic resonance imaging (MRI) — Baseline","Intramyocellular and extramyocellular fat fraction in muscle during magnetic resonance imaging (MRI) and magnetic reson…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cancer-and-aging","is_published":true,"match_reasons":["Title contains controlled term: cancer.","Abstract contains controlled term: cancer.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cancer and ageing","slug":"cancer-and-aging"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: muscle aging.","Source terminology contains: sarcopenia.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/5449","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}