{"type":"trials","record":{"id":56057,"source_id":"clinicaltrials-gov","external_id":"NCT06516237","title":"Development of Novel Imaging and Molecular Biomarkers of Fibrosis in Patient With Ulcerative Colitis","brief_summary":"Prospective multicenter interventional non-randomized cross-sectional study. Ultrasound operators will be blinded to clinical and endoscopic findings and the endoscopist will be blinded of the clinical and ultrasound findings. This study aims to develop novel imaging and molecular biomarkers of fibrosis, through the use of intestinal ultrasound and shear wave elastography, using histologic specimens obtained by endoscopic biopsies as reference standard.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"IRCCS San Raffaele","enrollment":50,"countries":["Italy"],"start_date":"2024-11-21","completion_date":"2026-07-31","last_update_date":"2026-01-15","source_url":"https://clinicaltrials.gov/study/NCT06516237","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T02:16:44.048862+00:00","last_seen_at":"2026-09-25T06:15:20.281+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"IRCCS San Raffaele","interventions":["to determine molecular and epigenetic biomarkers"],"registry_source":"ClinicalTrials.gov","outcome_measures":["To correlate ultrasound findings with histopathological elements of lesions — 1 day","To correlate shear wave elastography measurements with histopathological elements of lesions — 1 day"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Ulcerative Colitis","to determine molecular and epigenetic biomarkers"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: fibrosis.","quality_checked_at":"2026-09-25T06:15:30.843286+00:00","duplicate_cluster_key":"id:nct06516237","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-11-21 to 2026-07-31","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:20.330Z","intervention":["to determine molecular and epigenetic biomarkers"],"participants":50,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["To correlate ultrasound findings with histopathological elements of lesions — 1 day","To correlate shear wave elastography measurements with histopathological elements of lesions — 1 day"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"extracellular-matrix-aging","is_published":true,"match_reasons":["Title contains controlled term: fibrosis.","Abstract contains controlled term: fibrosis.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Extracellular matrix ageing","slug":"extracellular-matrix-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/56057","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}