{"type":"trials","record":{"id":7,"source_id":"clinicaltrials-gov","external_id":"NCT05949658","title":"Rapalog Pharmacology (RAP PAC) Study","brief_summary":"The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging. Participants who are 55-89 years old that are free of overt chronic diseases will be assigned to either 6 weeks of sirolimus or everolimus (5 mg, 10 mg, or 15 mg once per week). The investigators will complete the everolimus arm first and then subsequently complete the sirolimus arm of the study. Total time on study would be up to 17 weeks to complete baseline and follow up visits.","overall_status":"Recruiting","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of Wisconsin, Madison","enrollment":72,"countries":["United States"],"start_date":"2024-05-15","completion_date":"2028-12-01","last_update_date":"2026-05-28","source_url":"https://clinicaltrials.gov/study/NCT05949658","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-15T00:18:31.508+00:00","metadata":{"acronym":null,"organization":"University of Wisconsin, Madison","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05949658","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/7","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}