{"type":"trials","record":{"id":74,"source_id":"clinicaltrials-gov","external_id":"NCT07672522","title":"Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort","brief_summary":"This prospective observational cohort study aims to investigate the relationship between immunosenescence and infectious diseases in older adults. Individuals aged 60 years and older, including elderly patients with infections and healthy controls, will be enrolled and followed longitudinally. Clinical information, laboratory test results, and health assessment data will be collected. Biological specimens, including peripheral blood, urine, stool, sputum, and nasopharyngeal swabs, will be obtained during enrollment and follow-up. Participants will undergo regular assessments of health status, infection events, and aging-related clinical characteristics. The study will evaluate age-related changes in immune function, immune cell composition, immune receptor repertoires, epigenetic characteristics, metabolic profiles, and respiratory and gut microbiota. By integrating clinical and multi-omics data, the study aims to identify biomarkers associated with immunosenescence, susceptibility to infection, disease severity, and clinical outcomes in older adults. The results are expected to improve understanding of the mechanisms linking aging, immune dysfunction, and infectious diseases, and to support the development of predictive models and preventive strategies for infection management and healthy aging in elderly populations.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Huashan Hospital","enrollment":484,"countries":["China"],"start_date":"2024-11-29","completion_date":"2029-10-30","last_update_date":"2026-08-04","source_url":"https://clinicaltrials.gov/study/NCT07672522","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:59.105435+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Huashan Hospital","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Proportion of peripheral immune cell subset — Baseline to 5 years","DNA methylation level — Baseline to 5 years","Metabolite abundance (metabolomic profiling) — Baseline to 5 years","Respiratory and gut microbiota diversity measured by microbiome sequencing — Baseline to 5 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Immunosenescence"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct07672522","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-11-29 to 2029-10-30","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.072Z","intervention":[],"participants":484,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Proportion of peripheral immune cell subset — Baseline to 5 years","DNA methylation level — Baseline to 5 years","Metabolite abundance (metabolomic profiling) — Baseline to 5 years","Respiratory and gut microbiota diversity measured by microbiome sequencing — Baseline to 5 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence.","Source terminology contains: immunosenescence.","Title supplies longevity context: senescence, elderly.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/74","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}