{"type":"trials","record":{"id":85858,"source_id":"clinicaltrials-gov","external_id":"NCT03813082","title":"Age-related Changes in Sleep-wake Regulation","brief_summary":"A sleep deprivation protocol combined with state-of-the-art, simultaneous positron emission tomography and magnetic resonance spectroscopy imaging will be employed to investigate the effects of sleep deprivation and aging on hypothesized molecular markers of sleep need.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Zurich","enrollment":29,"countries":[],"start_date":"2016-03-01","completion_date":"2019-12-01","last_update_date":"2021-01-26","source_url":"https://clinicaltrials.gov/study/NCT03813082","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:26:02.039364+00:00","last_seen_at":"2026-09-25T03:26:01.923+00:00","metadata":{"acronym":null,"organization":"University of Zurich","source_has_results":false},"controlled_terms":["Sleep Deprivation","Prolonged wakefulness"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T03:26:03.36019+00:00","duplicate_cluster_key":"id:nct03813082","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-03-01 to 2019-12-01","comparator":null,"confidence":"structured-source","population":null,"provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:37:03.514931+00:00","intervention":[],"participants":29,"study_design":"INTERVENTIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":[],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/85858","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}