{"type":"trials","record":{"id":86106,"source_id":"isrctn","external_id":"ISRCTN13193281","title":"Does resistance training exercise help prevent frailty and loss of independence for older people with insulin treated diabetes? The EXPLODE Trial","brief_summary":"The aim of this trial is to characterise the physical function, cardiovascular health, and the health and wellbeing of older people living with diabetes, and compare that to a matched control group.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Newcastle upon Tyne Hospitals NHS Foundation Trust","enrollment":0,"countries":["United Kingdom","England"],"start_date":"2020-10-01","completion_date":"2025-04-01","last_update_date":"2026-09-01","source_url":"https://www.isrctn.com/ISRCTN13193281","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:01.576409+00:00","last_seen_at":"2026-09-26T06:27:09.416+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN13193281; retrieved 2026-09-26","interventions":["Behavioural"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Feasibility of carrying out a larger trial, measured using recruitment and retention rate, and the acceptability of int…","1. Body composition measured using height, weight, waist circumference, percentage body fat, and percentage fat-free ma…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Type 1 diabetes and type 2 diabetes treated with exogenous insulin","All participants will complete baseline blood and physical testing. Participants will then be randomised (1:1 ratio) to…","Nested study","Behavioural"],"relevance_confidence":80,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-26T06:27:09.96104+00:00","duplicate_cluster_key":"id:isrctn13193281","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-10-01 to 2025-04-01","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-26T06:27:09.424Z","intervention":["Behavioural"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Feasibility of carrying out a larger trial, measured using recruitment and retention rate, and the acceptability of int…","1. Body composition measured using height, weight, waist circumference, percentage body fat, and percentage fat-free ma…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as Interventional."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86106","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}