{"type":"trials","record":{"id":86167,"source_id":"isrctn","external_id":"ISRCTN12085208","title":"The effect of a low-calorie Mediterranean diet, intermittent fasting, and natural senolytics on aging markers in participants with low and high vascular risk","brief_summary":"Specific Objectives a. Biological aging and senescence To evaluate the effect of the combined intervention (hypocaloric MedDiet, intermittent fasting, and fisetin supplementation) on markers of cellular senescence and biological aging, including senescent cell burden, inflammatory markers, mitochondrial dysfunction, progenitor cell depletion, telomere length, and DNA methylation, compared with a hypocaloric MedDiet alone, in participants with high or very high and low or moderate cardiovascular risk across both age groups. b. Subclinical cardiovascular disease To assess the effect of the combined intervention on subclinical CVD, evaluated using imaging and functional vascular techniques, compared with a hypocaloric MedDiet alone, in participants with high or very high vs. low or moderate cardiovascular risk across both age groups. c. Physical function and frailty To evaluate the effect of the combined intervention on physical function, including sarcopenia and frailty status, compared with a hypocaloric MedDiet alone, in participants with high or very high and low or moderate cardiovascular risk across both age groups. d. Advanced glycation end-products. To assess the effect of th…","overall_status":"Recruiting","phases":[],"study_type":"Interventional","sponsor":"Instituto de Salud Carlos III","enrollment":0,"countries":["Spain"],"start_date":"2026-01-01","completion_date":"2030-01-01","last_update_date":"2026-01-22","source_url":"https://www.isrctn.com/ISRCTN12085208","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:29.369042+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN12085208; retrieved 2026-09-25","interventions":["Mixed"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":[],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Prevention of aging in patients with low to very high cardiovascular risk","All participants will undergo a standardized medical and lifestyle assessment, including detailed information on alcoho…","Protocol file","Statistical Analysis Plan","Mixed"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: senolytic.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn12085208","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-01-01 to 2030-01-01","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.025Z","intervention":["Mixed"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":[],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"mediterranean-diet","is_published":true,"match_reasons":["Title contains controlled term: mediterranean diet.","Title supplies longevity context: aging.","Study type is explicitly identified as Interventional."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Mediterranean diet","slug":"mediterranean-diet"}},{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: senolytic.","Abstract contains controlled term: cellular senescence, senescent cell.","Title supplies longevity context: aging.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86167","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}