{"type":"trials","record":{"id":86171,"source_id":"isrctn","external_id":"ISRCTN47919839","title":"Assessment of the effect of geroprotectors on how cells work in the human body","brief_summary":"Does a 3-week course of metformin, spermidine, or fisetin reduce the number of senescent cells as measured by SA-β-GAL in adipose biopsies in healthy older volunteers?","overall_status":"Completed","phases":["Phase II"],"study_type":"Interventional","sponsor":"University of Birmingham","enrollment":0,"countries":["United Kingdom","England"],"start_date":"2024-11-01","completion_date":"2026-06-30","last_update_date":"2026-06-22","source_url":"https://www.isrctn.com/ISRCTN47919839","editorial_summary":"A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:30.109+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN47919839; retrieved 2026-09-25","interventions":["Metformin MR, fisetin, spermidine","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Number of senescent cells in adipose tissue measured by the SA-β-GAL technique after 3 weeks of intervention, adjusted…","1. Senescent cell burden in adipose tissue as measured by transcriptomics using SenMayo analysis after 3 weeks of inter…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Ageing","TRIAL DESIGN A Phase IIa clinical trial of a 3-week intervention of one of three geroprotector drugs: metformin MR, fis…","Protocol file","Metformin MR, fisetin, spermidine","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: metformin.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn47919839","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-11-01 to 2026-06-30","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.047Z","intervention":["Metformin MR, fisetin, spermidine","Drug"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase II","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of senescent cells in adipose tissue measured by the SA-β-GAL technique after 3 weeks of intervention, adjusted…","1. Senescent cell burden in adipose tissue as measured by transcriptomics using SenMayo analysis after 3 weeks of inter…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Source terminology supplies longevity context: ageing.","Study type is explicitly identified as Interventional."],"matched_fields":["abstract","controlled terminology","controlled context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86171","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}