{"type":"trials","record":{"id":86172,"source_id":"isrctn","external_id":"ISRCTN16898870","title":"The effect of physical exercise on markers of aging","brief_summary":"The 24-week physical exercise intervention has a beneficial effect on phenotypic age and phenotypic age acceleration and other phenotypic markers of aging in people approaching later life.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Folkhälsans Forskningscentrum","enrollment":150,"countries":["Finland"],"start_date":"2022-08-01","completion_date":"2025-12-31","last_update_date":"2023-10-03","source_url":"https://www.isrctn.com/ISRCTN16898870","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:30.109+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN16898870; retrieved 2026-09-25","interventions":["Behavioural"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Phenotypic age measured using a fasting blood sample as a linear combination of chronological age and nine multisyst…","1. (Relative) leucocyte telomere length is measured from whole blood leukocyte DNA using quantitative real-time polymer…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Effects of physical exercise on markers of aging in physically inactive adults approaching later life","Participants are randomized 1:1 either to the control group or the exercise intervention group after all the baseline m…","Study website","Behavioural"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn16898870","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-08-01 to 2025-12-31","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.074Z","intervention":["Behavioural"],"participants":150,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Phenotypic age measured using a fasting blood sample as a linear combination of chronological age and nine multisyst…","1. (Relative) leucocyte telomere length is measured from whole blood leukocyte DNA using quantitative real-time polymer…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: aging.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86172","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}