{"type":"trials","record":{"id":86174,"source_id":"isrctn","external_id":"ISRCTN29932357","title":"Can metformin prevent worsening of muscle weakness and frailty in older people who are showing early signs of frailty?","brief_summary":"4 months of metformin 500 mg three times a day will improve measures of physical performance in older people with sarcopenia and prefrailty.","overall_status":"Completed","phases":["Phase IV"],"study_type":"Interventional","sponsor":"Newcastle upon Tyne Hospitals NHS Foundation Trust","enrollment":72,"countries":["United Kingdom","England"],"start_date":"2021-04-01","completion_date":"2023-08-31","last_update_date":"2026-04-28","source_url":"https://www.isrctn.com/ISRCTN29932357","editorial_summary":"A registered Phase IV study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:30.109+00:00","last_seen_at":"2026-09-25T03:45:34.377+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN29932357; retrieved 2026-09-25","interventions":["Metformin hydrochloride","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["4-m walk speed at 4 months","1. Fried frailty score, including individual components: 1.1. Activity level assessed using self-report questionnaire a…"],"design_description":"Interventional","source_has_results":true},"controlled_terms":["Frailty and sarcopenia in older people","Participants will be randomised 1:1 into the metformin or placebo arms using a web-based randomisation system. They wil…","Post hoc secondary analysis","Basic results","Plain English results","Metformin hydrochloride","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-25T03:45:36.517565+00:00","duplicate_cluster_key":"id:isrctn29932357","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-04-01 to 2023-08-31","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:45:34.466Z","intervention":["Metformin hydrochloride","Drug"],"participants":72,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase IV","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["4-m walk speed at 4 months","1. Fried frailty score, including individual components: 1.1. Activity level assessed using self-report questionnaire a…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86174","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}