{"type":"trials","record":{"id":86201,"source_id":"isrctn","external_id":"ISRCTN11237599","title":"A study to evaluate the effects of the combination of GI-102 with GIB-7 on biomarkers of aging in healthy adults and cancer survivors","brief_summary":"This phase 2a clinical study (GIANTS-1) aims to evaluate a novel dual combination strategy using GI-102 and GIB-7 to address key pathological features of aging, including immunosenescence (the aging of the immune system), metabolic dysfunction, and gut-brain-muscle axis dysregulation.","overall_status":"Recruiting","phases":[],"study_type":"Interventional","sponsor":"GI Innovation, Inc.","enrollment":0,"countries":["Australia","Korea, South"],"start_date":"2026-01-27","completion_date":"2026-10-01","last_update_date":"2026-05-20","source_url":"https://www.isrctn.com/ISRCTN11237599","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN11237599; retrieved 2026-09-25","interventions":["Mixed"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":[],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Cancer Survivors, Healthy Participant, Elderly","The dose of randomisation is 0.02 mg/kg of GI-102. The method of randomisation is centralized, stratified randomization…","Mixed"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: cancer.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn11237599","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-01-27 to 2026-10-01","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.025Z","intervention":["Mixed"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":[],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cancer-and-aging","is_published":true,"match_reasons":["Title contains controlled term: cancer.","Source terminology contains: cancer.","Title supplies longevity context: aging.","Study type is explicitly identified as Interventional."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cancer and ageing","slug":"cancer-and-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86201","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}