{"type":"trials","record":{"id":86214,"source_id":"isrctn","external_id":"ISRCTN13303580","title":"Resistance and aerobic exercise with protein in older adults with obesity during energy restriction","brief_summary":"The main questions this study aims to address are: 1. Does a higher dietary protein intake (1.6 g protein/kg body mass/day) improve lean mass retention compared to a normal protein intake (0.8 g protein/kg body mass/day) when consumed in combination with exercise and energy restriction? 2. How do these dietary protein levels affect myofibrillar protein synthesis in older adults with obesity?","overall_status":"Recruiting","phases":[],"study_type":"Interventional","sponsor":"University of Birmingham","enrollment":60,"countries":["United Kingdom","England"],"start_date":"2024-09-16","completion_date":"2026-09-27","last_update_date":"2025-08-15","source_url":"https://www.isrctn.com/ISRCTN13303580","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T03:45:34.377+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN13303580; retrieved 2026-09-25","interventions":["Other"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Total and regional lean mass measured using DXA at PRE (Day 0), POST (Day 28) and 3-month follow-up (Day 112)","1. Total and regional fat mass measured using DXA at PRE (Day 0), POST (Day 28) and 3-month follow-up (Day 112) 2. Body…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Overweight or obesity","Participants will be block randomised to one of three groups, stratified by sex. Randomisation will be performed using…","Study website","Participant information sheet","Other"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T03:45:36.517565+00:00","duplicate_cluster_key":"id:isrctn13303580","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-16 to 2026-09-27","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:45:34.397Z","intervention":["Other"],"participants":60,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Total and regional lean mass measured using DXA at PRE (Day 0), POST (Day 28) and 3-month follow-up (Day 112)","1. Total and regional fat mass measured using DXA at PRE (Day 0), POST (Day 28) and 3-month follow-up (Day 112) 2. Body…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86214","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}