{"type":"trials","record":{"id":86246,"source_id":"isrctn","external_id":"ISRCTN14284561","title":"Effectiveness of an oral nutrition supplementation enriched with HMB and UC-II® combined with exercise training in older adults with knee osteoarthritis","brief_summary":"Current study hypothesis as of 22/11/2024: 12 weeks of oral nutrition supplementation enriched with HMB and UC-II® combined with exercise training can reduce OA-related symptoms, improve OA-related biomarkers, body composition, morphological changes of OA condition as well as gene expression profile among adults with knee OA. _____ Previous study hypothesis: 1. Oral nutrition supplementation enriched with HMB and UC-II® can improve body composition among older adults with knee osteoarthritis (OA). 2. Oral nutrition supplementation enriched with HMB and UC-II® can improve inflammatory biomarkers among older adults with knee OA. 3. Oral nutrition supplementation enriched with HMB and UC-II® can reduce pain, stiffness and physical function among older adults with knee OA. 4. Oral nutrition supplementation enriched with HMB and UC-II® can improve morphological change of OA condition using magnetic resonance imaging among older adults with knee OA. 5. Oral nutrition supplementation enriched with HMB and UC-II® can sustain its positive impact on body composition, OA-related symptoms, inflammatory biomarkers and morphological change of OA condition among older adults with knee OA after 1…","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Powerlife (M) Sdn. Bhd.","enrollment":90,"countries":["Malaysia"],"start_date":"2024-06-01","completion_date":"2025-12-31","last_update_date":"2025-06-20","source_url":"https://www.isrctn.com/ISRCTN14284561","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN14284561; retrieved 2026-09-25","interventions":["Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Current primary outcome measure as of 22/11/2024: 1. OA-related symptoms (or the severity of OA symptoms) measured usin…","Current secondary outcome measures as of 22/11/2024: 1. Body composition measured using bioelectric impedance analyzer…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Knee osteoarthritis","Current interventions as of 22/11/2024: There will be two interventional groups in this study, which are the study grou…","Supplement"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn14284561","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-06-01 to 2025-12-31","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.052Z","intervention":["Supplement"],"participants":90,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Current primary outcome measure as of 22/11/2024: 1. OA-related symptoms (or the severity of OA symptoms) measured usin…","Current secondary outcome measures as of 22/11/2024: 1. Body composition measured using bioelectric impedance analyzer…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: older adult.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86246","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}