{"type":"trials","record":{"id":86310,"source_id":"isrctn","external_id":"ISRCTN75429638","title":"Multi-component intervention for the reversal of mild cognitive impairment and physical frailty","brief_summary":"1. Multi-domain modality intervention has the ability to reverse cognitive frailty among older adults 2. Physiological, vascular health and nutritional status would influence responses towards multi-domain modality intervention to reverse cognitive frailty among older adults 3. Environmental and psychosocial factors influence adherence towards multi-domain modality intervention to reverse cognitive frailty among older adults","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"National University of Malaysia","enrollment":106,"countries":["Malaysia"],"start_date":"2020-11-23","completion_date":"2024-05-12","last_update_date":"2025-06-11","source_url":"https://www.isrctn.com/ISRCTN75429638","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T03:47:42.83+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN75429638; retrieved 2026-09-25","interventions":["Mixed"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Current primary outcome measure as of 11/06/2025: The primary outcomes assessed in this study encompassed both cognitiv…","Current secondary outcome measures as of 11/06/2025: 1.15ml blood will be drawn to examine the vascular health that inc…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Cognitive frailty in older adults","Current interventions as of 11/06/2025: The intervention group participated in a structured 24-month program, which beg…","A qualitative study on the impact and participation in the AGELESS multidomain intervention: Insights from older adults…","Development and Evaluation of Content Validity and Acceptance of a Multidomain Intervention Module for Reversal of Cogn…","Recruitment and Baseline Characteristics of Participants","Study website","Mixed"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T03:47:47.490686+00:00","duplicate_cluster_key":"id:isrctn75429638","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-11-23 to 2024-05-12","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:47:42.836Z","intervention":["Mixed"],"participants":106,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Current primary outcome measure as of 11/06/2025: The primary outcomes assessed in this study encompassed both cognitiv…","Current secondary outcome measures as of 11/06/2025: 1.15ml blood will be drawn to examine the vascular health that inc…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86310","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}