{"type":"trials","record":{"id":86332,"source_id":"isrctn","external_id":"ISRCTN46458028","title":"Diet and Exercise for FRAILty: DEFRAIL","brief_summary":"That a novel exercise and nutritional intervention, developed by expert consensus to be feasible for delivery to groups of frail older adults in a community-setting by non-medical professionals, can improve clinical and biochemical markers of frailty","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Royal College of Surgeons in Ireland","enrollment":24,"countries":["Ireland"],"start_date":"2019-01-02","completion_date":"2020-07-12","last_update_date":"2023-07-19","source_url":"https://www.isrctn.com/ISRCTN46458028","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T03:45:58.406+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN46458028; retrieved 2026-09-25","interventions":["Mixed"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Frailty assessed by Fried frailty criteria comprised of identification of weak grip strength, slow gait speed, excessiv…","1. Falls risk as assessed by the Timed Up & Go (TUG) test at baseline, 8 and 16 weeks 2. Functional leg strength assess…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Frailty","The intervention is an eight-week program of multi-component resistance, aerobic, balance, and flexibility) exercise cl…","Uploaded 03/07/2020","Mixed"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T03:45:58.510232+00:00","duplicate_cluster_key":"id:isrctn46458028","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-01-02 to 2020-07-12","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:45:58.406Z","intervention":["Mixed"],"participants":24,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frailty assessed by Fried frailty criteria comprised of identification of weak grip strength, slow gait speed, excessiv…","1. Falls risk as assessed by the Timed Up & Go (TUG) test at baseline, 8 and 16 weeks 2. Functional leg strength assess…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86332","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}