{"type":"trials","record":{"id":86368,"source_id":"isrctn","external_id":"ISRCTN76069316","title":"The impact of cranberries on microbiome and brain in healthy ageing","brief_summary":"Healthy older adults will be provided with a high-polyphenol, freeze-dried cranberry powder study food to take daily for 12 weeks, following which it is hypothesized that there will be increased gut microflora diversity and quantity of health-promoting bacterial species as measured in stool samples, which will relate to improved brain function and cognition, and decreased biomarkers of disease processes related to neurodegeneration.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"University of East Anglia","enrollment":60,"countries":["United Kingdom","England"],"start_date":"2018-10-02","completion_date":"2020-05-21","last_update_date":"2022-12-02","source_url":"https://www.isrctn.com/ISRCTN76069316","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T03:45:47.973+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN76069316; retrieved 2026-09-25","interventions":["Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Gut microflora speciation and metabolism is measured by analysing stool samples at baseline and at the 12-weeks foll…","1. Changes in energy expenditure and sleep measured using actigraphs worn for one week prior to baseline and one week p…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Brain function in healthy older people","Participants will be randomised using a computerised randomisation algorithm into one of two intervention arms: the act…","Uploaded 13/11/2018","Protocol file","Supplement"],"relevance_confidence":80,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: microbiome.","quality_checked_at":"2026-09-25T03:45:48.27173+00:00","duplicate_cluster_key":"id:isrctn76069316","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-10-02 to 2020-05-21","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:45:47.989Z","intervention":["Supplement"],"participants":60,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Gut microflora speciation and metabolism is measured by analysing stool samples at baseline and at the 12-weeks foll…","1. Changes in energy expenditure and sleep measured using actigraphs worn for one week prior to baseline and one week p…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"microbiome-dysbiosis","is_published":true,"match_reasons":["Title contains controlled term: microbiome.","Title supplies longevity context: ageing.","Study type is explicitly identified as Interventional."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Microbiome and dysbiosis","slug":"microbiome-dysbiosis"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86368","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}