{"type":"trials","record":{"id":86389,"source_id":"isrctn","external_id":"ISRCTN64199452","title":"Effects of dietary protein distribution and resistance exercise training on muscle health in older adults","brief_summary":"There will be a significant difference in muscle health with different protein distributions. Based on previous studies, we hypothesise that improvements will be seen in both groups, however there will be greater improvement in the Pulse group.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"University of Birmingham","enrollment":12,"countries":["United Kingdom","England"],"start_date":"2016-04-18","completion_date":"2018-06-30","last_update_date":"2019-07-05","source_url":"https://www.isrctn.com/ISRCTN64199452","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:34.939462+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"Female","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN64199452; retrieved 2026-09-25","interventions":["Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Muscle protein synthesis is measured using D2O tracer, muscle biopsies and saliva samples at baseline and day 14","1. Leg extension strength is measured using 1-RM tests at baseline and day 14 2. Serum inflammatory markers IL-1, IL-6,…"],"design_description":"Interventional","source_has_results":true},"controlled_terms":["Sarcopenia","Participants are randomly allocated to one of two groups, and receive a set of meal plans to follow for two weeks. Part…","Uploaded 02/04/2019","uploaded 05/07/2019","Supplement"],"relevance_confidence":80,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn64199452","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-04-18 to 2018-06-30","comparator":null,"confidence":"structured-source","population":"Female · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.134Z","intervention":["Supplement"],"participants":12,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Muscle protein synthesis is measured using D2O tracer, muscle biopsies and saliva samples at baseline and day 14","1. Leg extension strength is measured using 1-RM tests at baseline and day 14 2. Serum inflammatory markers IL-1, IL-6,…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as Interventional."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86389","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}