{"type":"trials","record":{"id":86582,"source_id":"isrctn","external_id":"ISRCTN93189645","title":"Reverse the clock: a clinical trial of collagen activator effects on biological age and skin quality","brief_summary":"Primary objective: Intake of the collagen activator from Avea for 6 months will result in a significant decrease in biological age compared to the baseline. Secondary objective: Intake of the collagen activator from Avea will lead to a significant improvement in skin quality and texture, including increased hydration, elasticity, and reduction in wrinkles, pigmentation, texture, UV-spots, pores, redness, and porphyrins after 3 months compared to baseline.","overall_status":"Completed","phases":[],"study_type":"Observational","sponsor":"Avea Life AG","enrollment":66,"countries":["Switzerland"],"start_date":"2023-10-02","completion_date":"2024-10-14","last_update_date":"2025-11-21","source_url":"https://www.isrctn.com/ISRCTN93189645","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:40.539426+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN93189645; retrieved 2026-09-25","interventions":["Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Changes in DNA methylation patterns as a biomarker of biological age using TruMe DNA test at Baseline and Month-6.","1. Hydration, measured using the corneometer at Baseline, Month-1, and Month-3. 2. Elasticity, measured using the cutom…"],"design_description":"Observational","source_has_results":false},"controlled_terms":["Efficacy of Collagen supplementation in improving skin quality and reducing the signs of skin aging.","The study is a human research study in which customers that are taking the collagen activator from Avea are observed fo…","Protocol file","Participant information sheet","Supplement"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn93189645","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-10-02 to 2024-10-14","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.035Z","intervention":["Supplement"],"participants":66,"study_design":"Observational","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Changes in DNA methylation patterns as a biomarker of biological age using TruMe DNA test at Baseline and Month-6.","1. Hydration, measured using the corneometer at Baseline, Month-1, and Month-3. 2. Elasticity, measured using the cutom…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Abstract contains controlled term: biological age.","Title supplies longevity context: biological age.","Study type is explicitly identified as Observational."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86582","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}