{"type":"trials","record":{"id":86616,"source_id":"isrctn","external_id":"ISRCTN77611378","title":"Anti-inflammatory supplement to reduce immune ageing","brief_summary":"To test the hypothesis that a 12-week treatment of Essentials, a nutritional supplement developed by Bayer, will improve biological ageing, immune ageing, quality of life (QoL), and physical function (SPPB) in healthy older adults, by conducting an uncontrolled open label trial in 76 participants.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"University of Birmingham","enrollment":83,"countries":["United Kingdom","England"],"start_date":"2022-10-01","completion_date":"2024-05-01","last_update_date":"2026-05-01","source_url":"https://www.isrctn.com/ISRCTN77611378","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:43.937595+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN77611378; retrieved 2026-09-25","interventions":["Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Immune ageing by measuring 51 different serum cytokines, chemokines and growth factors to give an iAGE score (Sayed et…","At baseline and 12 weeks we will measure 1. Biological ageing by DNA methylation in peripheral blood and saliva; 2. QoL…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Age related inflammation and DNA methylation","This trial will test the hypothesis that a combination of vitamins and nutraceuticals (“Essentials”), all known to have…","Participant information sheet","Protocol file","Supplement"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: immune ageing.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn77611378","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-10-01 to 2024-05-01","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.054Z","intervention":["Supplement"],"participants":83,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Immune ageing by measuring 51 different serum cytokines, chemokines and growth factors to give an iAGE score (Sayed et…","At baseline and 12 weeks we will measure 1. Biological ageing by DNA methylation in peripheral blood and saliva; 2. QoL…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immune ageing.","Abstract contains controlled term: immune ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86616","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}