{"type":"trials","record":{"id":86744,"source_id":"isrctn","external_id":"ISRCTN23294745","title":"Dietary supplements, exercise, and muscle ageing","brief_summary":"Dietary interventions (e.g. protein and nitrate) and exercise can modulate muscle ageing throughout the lifecourse.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"University of Bradford","enrollment":420,"countries":["United Kingdom","England"],"start_date":"2023-01-30","completion_date":"2024-10-01","last_update_date":"2023-03-27","source_url":"https://www.isrctn.com/ISRCTN23294745","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:45:55.470179+00:00","last_seen_at":"2026-09-25T04:04:16.009+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN23294745; retrieved 2026-09-25","interventions":["Mixed"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Physical function measured using isokinetic dynamometer of knee extension and flexion at baseline and follow-up visits…","1. Hand grip strength quantified using an isometric dynamometer at baseline, 3, 6, 9 and 12 months 2. Rate of force dev…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Skeletal muscle ageing throughout the life course (aged 18+ years)","Participants will undertake the intervention for up to 12 months. For single interventions (e.g. nitrate only, protein…","Mixed"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: muscle ageing.","quality_checked_at":"2026-09-25T04:04:25.705398+00:00","duplicate_cluster_key":"id:isrctn23294745","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-01-30 to 2024-10-01","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:04:16.069Z","intervention":["Mixed"],"participants":420,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Physical function measured using isokinetic dynamometer of knee extension and flexion at baseline and follow-up visits…","1. Hand grip strength quantified using an isometric dynamometer at baseline, 3, 6, 9 and 12 months 2. Rate of force dev…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: muscle ageing.","Abstract contains controlled term: muscle ageing.","Source terminology contains: muscle ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86744","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}