{"type":"trials","record":{"id":86989,"source_id":"isrctn","external_id":"ISRCTN14722819","title":"PHOENIX-Feasibility: picking up hidden osteoporosis effectively during normal CT imaging without additional x-rays","brief_summary":"It is hypothesised there will be value in early diagnosis and treatment of osteoporosis, through fractures prevented, societal and social burden and reduced health costs. The current usual care for case-finding osteoporosis in older people is for the GP to ask their patient to complete a FRAX questionnaire. The responses to these 11 questions regarding fracture risk factors are then entered by the GP into an online calculator which indicates whether a DXA scan should be requested. Uptake of case finding is low and there is no national mandate for screening. High-risk patients are referred for a DXA scan and treatment is offered if the bone mineral density (BMD) is low and/or fracture risk sufficiently high. Vertebral fractures are rarely detected in usual care even though they (alongside hip fractures) cause the biggest burden to patients and the health service. The expectation is that targeted screening will improve upon usual care and appropriately increase the diagnostic rate. There are several reasons for opportunistic osteoporosis screening during a CT scan: 1. CT attenders are a high-risk population; >30% of these older adults have undiagnosed vertebral fractures or osteopor…","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Cambridge University NHS Foundation Trust","enrollment":625,"countries":["United Kingdom","England"],"start_date":"2019-10-29","completion_date":"2024-12-30","last_update_date":"2024-07-29","source_url":"https://www.isrctn.com/ISRCTN14722819","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:28.783517+00:00","last_seen_at":"2026-09-25T03:46:28.269+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN14722819; retrieved 2026-09-25","interventions":["Other"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Recruitment rate recorded as the number of eligible participants who consent to participate in the study in 10 month…","There are no secondary outcome measures"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Osteoporosis","Current intervention: The intervention is a FRAX questionnaire and a review of CT scans repurposed to look for vertebra…","Study website","Uploaded 15/08/2019","Other"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: osteoporosis.","quality_checked_at":"2026-09-25T03:46:32.075789+00:00","duplicate_cluster_key":"id:isrctn14722819","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-29 to 2024-12-30","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:28.283Z","intervention":["Other"],"participants":625,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Recruitment rate recorded as the number of eligible participants who consent to participate in the study in 10 month…","There are no secondary outcome measures"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"bone-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoporosis.","Abstract contains controlled term: osteoporosis.","Source terminology contains: osteoporosis.","Title supplies longevity context: aging.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Bone ageing","slug":"bone-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/86989","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}