{"type":"trials","record":{"id":87100,"source_id":"isrctn","external_id":"ISRCTN11083692","title":"A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)","brief_summary":"Primary objective: To assess the long-term safety and how well participants can tolerate (tolerability) JNJ-81201887, when given as an injection into the eye in parent clinical studies (81201887MDG2001, 81201887MDG1003).","overall_status":"Recruiting","phases":["Phase II"],"study_type":"Interventional","sponsor":"Janssen-Cilag International N.V.","enrollment":0,"countries":["United Kingdom","Australia","Belgium","Canada","Czech Republic","Denmark","Germany","Hungary","Italy","Netherlands","Poland","Portugal","Spain","Sweden","Switzerland","Türkiye","United States of America","England"],"start_date":"2024-09-19","completion_date":"2029-08-29","last_update_date":"2026-03-10","source_url":"https://www.isrctn.com/ISRCTN11083692","editorial_summary":"A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN11083692; retrieved 2026-09-25","interventions":["AAVCAGsCD59, prednisone","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. The number of participants with ocular and systemic TEAEs will be reported. An adverse event (AE) is any untoward me…","There are no secondary outcome measures"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Geographic Atrophy, secondary to age-related macular degeneration","Study participants who were enrolled and received treatment with low dose JNJ-81201887 in parent clinical studies (8120…","AAVCAGsCD59, prednisone","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn11083692","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-19 to 2029-08-29","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.557Z","intervention":["AAVCAGsCD59, prednisone","Drug"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase II","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. The number of participants with ocular and systemic TEAEs will be reported. An adverse event (AE) is any untoward me…","There are no secondary outcome measures"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87100","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}