{"type":"trials","record":{"id":87105,"source_id":"isrctn","external_id":"ISRCTN82949875","title":"Saponins for macular disease","brief_summary":"To establish whether treatment of age-related macular degeneration (AMD) with oral glycoside supplements is feasible and acceptable to participants.","overall_status":"Recruiting","phases":["Phase II"],"study_type":"Interventional","sponsor":"Cardiff University","enrollment":0,"countries":["United Kingdom","England","Wales"],"start_date":"2025-04-01","completion_date":"2026-12-31","last_update_date":"2026-02-02","source_url":"https://www.isrctn.com/ISRCTN82949875","editorial_summary":"A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Mixed","comparator":null,"attribution":"Source: ISRCTN ISRCTN82949875; retrieved 2026-09-25","interventions":["Triterpenoid saponins","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["The feasibility of a subsequent fully powered trial, assessed using: 1. Recruitment: the proportion of those contacted…","Measured at baseline, 4 and 12 months: 1. Dark adaptation with calculation of cone tau(s), rod cone break time (s) and…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Men and women with early or intermediate stage age-related macular degeneration (AMD) in the trial eye and any stage of…","Randomisation will take place at baseline visit 2 (up to 3 weeks after baseline visit 1) when eligibility has been conf…","Triterpenoid saponins","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":85,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn82949875","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-01 to 2026-12-31","comparator":null,"confidence":"structured-source","population":"All · Mixed","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.560Z","intervention":["Triterpenoid saponins","Drug"],"participants":0,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase II","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The feasibility of a subsequent fully powered trial, assessed using: 1. Recruitment: the proportion of those contacted…","Measured at baseline, 4 and 12 months: 1. Dark adaptation with calculation of cone tau(s), rod cone break time (s) and…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87105","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}