{"type":"trials","record":{"id":87106,"source_id":"isrctn","external_id":"ISRCTN85022211","title":"Using panitumumab with ranibizumab injected into the eye to treat exudative age-related macular degeneration","brief_summary":"Subretinal fibrosis in exudative macular diseases such as exudative age-related macular degeneration consists of prolifereated retinal pigment epithelium (RPE) cells. RPE cells have epidermal growth factor (EGF) receptors, and in cell culture, RPE cell migration and proliferation is reduced by application of EGF receptor blockers. We hypothesize, that addition of panitumumab as an EGF receptor blocker reduces the subretinal fibrotic scar formation in eyes with exudative, neovascular age-related macular degeneration","overall_status":"Recruiting","phases":["Phase II"],"study_type":"Interventional","sponsor":"Ufa Eye Research Institute","enrollment":200,"countries":["Russian Federation"],"start_date":"2023-12-01","completion_date":"2026-12-31","last_update_date":"2023-12-27","source_url":"https://www.isrctn.com/ISRCTN85022211","editorial_summary":"A registered Phase II study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN85022211; retrieved 2026-09-25","interventions":["Panitumumab","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Change in the retinal thickness in the foveola, as measured from Bruch´s membrane to the inner limiting membrane (i.…","At baseline, at the time of the injections and re-injections, and at study end using optical coherence tomography: 1. A…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Exudative age-related macular degeneration","This is a 2-year, prospective, randomized, double-masked, controlled study of the safety and efficacy of repeated intra…","Panitumumab","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn85022211","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-12-01 to 2026-12-31","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.560Z","intervention":["Panitumumab","Drug"],"participants":200,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase II","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Change in the retinal thickness in the foveola, as measured from Bruch´s membrane to the inner limiting membrane (i.…","At baseline, at the time of the injections and re-injections, and at study end using optical coherence tomography: 1. A…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87106","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}