{"type":"trials","record":{"id":87118,"source_id":"isrctn","external_id":"ISRCTN13798759","title":"Prediction of conversion to wet age-related macular degeneration (AMD)","brief_summary":"Age related macular degeneration is a leading cause of visual loss. Early detection and intervention of advanced neovascular AMD have been shown to improve visual outcomes. Once nAMD develops in one eye there is higher risk of subsequent development of choroidal neovascularization in the second eye. In a person with unilateral wAMD (exudative AMD), the risk of the contralateral or fellow eye also converting to wAMD is 10% per year from the time the first eye develops wAMD. However, not all patients convert in first year and so by 5 years, the risk of conversion is 50%. This makes it difficult to counsel patients of their risk as they can convert at anytime in the 5 years and sometimes even later. Better prediction tools are required. Numerous imaging related risk factors have been studied for conversion of to neovascular AMD in fellow eyes of patients with unilateral exudative AMD. There is sufficient evidence that subclinical non-exudative choroidal neovascularisation (subclinical CNV) detected by OCTA exist before the eyes convert to exudative AMD. The incidence and prevalence of subclinical CNV is unclear and whether it is the strongest predictor for conversion is also unclear.…","overall_status":"Completed","phases":[],"study_type":"Observational","sponsor":"Moorfields Eye Hospital NHS Foundation Trust","enrollment":862,"countries":["United Kingdom","England","Northern Ireland"],"start_date":"2021-04-20","completion_date":"2025-01-01","last_update_date":"2026-04-10","source_url":"https://www.isrctn.com/ISRCTN13798759","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN13798759; retrieved 2026-09-25","interventions":["Procedure/Surgery"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Age, gender, ethnicity, smoking history, and date of anti-Vascular Endothelial Growth Factor injection of non-study…","There are no secondary outcome measures"],"design_description":"Observational","source_has_results":false},"controlled_terms":["Age-related macular degeneration","This is a non-interventional cohort study and divided into a retrospective and prospective part. The retrospective part…","Procedure/Surgery"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn13798759","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-04-20 to 2025-01-01","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.566Z","intervention":["Procedure/Surgery"],"participants":862,"study_design":"Observational","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Age, gender, ethnicity, smoking history, and date of anti-Vascular Endothelial Growth Factor injection of non-study…","There are no secondary outcome measures"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Observational."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87118","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}