{"type":"trials","record":{"id":87132,"source_id":"isrctn","external_id":"ISRCTN60434145","title":"TGF-βs in the eye of patients with neovascular age-related macular degeneration","brief_summary":"The aim of this study is to evaluate the protein concentration of active TGF-β1, TGF-β2, and TGF-β3 in the aqueous humor of patients affected by naïve nAMD, at baseline and after intravitreal anti-VEGF-A injection by performing a luciferase-based reporter assay to test the TGF-β pathway activation by aqueous humor samples of the same patients, with the aim to clarify the role of the TGF-β family members in CNV.","overall_status":"Completed","phases":["Not Applicable"],"study_type":"Observational","sponsor":"University of Siena","enrollment":40,"countries":["Italy"],"start_date":"2016-06-01","completion_date":"2017-06-21","last_update_date":"2018-12-10","source_url":"https://www.isrctn.com/ISRCTN60434145","editorial_summary":"A registered Not Applicable study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN60434145; retrieved 2026-09-25","interventions":["Ranibizumab","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. TGF-beta concentration is measured using ELISA kits for human TGF-β1, TGF-β2 (Quantikine ELISA kits #DB100B and #DB2…","There were no secondary outcomes of interest."],"design_description":"Observational","source_has_results":false},"controlled_terms":["Age-related macular degeneration (AMD)","We measure the concentrations of active TGF-β1, TGF-β2, and TGF-β3 by ELISA in the aqueous humor of patients affected b…","results","Ranibizumab","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn60434145","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-06-01 to 2017-06-21","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.573Z","intervention":["Ranibizumab","Drug"],"participants":40,"study_design":"Observational","subject_scope":"Human clinical study registration","evidence_stage":"Not Applicable","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. TGF-beta concentration is measured using ELISA kits for human TGF-β1, TGF-β2 (Quantikine ELISA kits #DB100B and #DB2…","There were no secondary outcomes of interest."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Observational."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87132","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}