{"type":"trials","record":{"id":87135,"source_id":"isrctn","external_id":"ISRCTN16689192","title":"The effect of 670 nm light on visual function in ageing and age-related macular degeneration","brief_summary":"Photoreceptors demand more energy than other tissue in the body. Unfortunately, as people grow older, mitochondria become less efficient and produce less energy. This is associated with inflammation which contributes to age-related macular degeneration (AMD) and aging in general. AMD is the commonest cause of blindness in the elderly and unfortunately, there is no prevention or cure for this. A molecule in mitochondria can absorb a particular wavelength of light (670nm – which is red) and increase energy production. This has been shown in different cells, including the retina. Studies have also shown that inflammation associated with aging and AMD is reduced by exposure to this red light. This is a pilot study to see if exposure to 670 nm wavelength of light can improve visual function in aging and AMD.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"University College London","enrollment":40,"countries":["United Kingdom","England"],"start_date":"2017-03-29","completion_date":"2019-02-02","last_update_date":"2017-07-27","source_url":"https://www.isrctn.com/ISRCTN16689192","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN16689192; retrieved 2026-09-25","interventions":["Device"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Visual function determined by photoreceptor function over time, measured at 1, 3, 6 and 12 months","Measured at 1, 3, 6 and 12 months: 1. Metrics of photoreceptor function, assessed psychophysically and electrophysiolog…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Dry age-related macular degeneration","Participants will hold a device emitting 670 nm light to their eyes for two minutes every day for one year and have the…","Device"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn16689192","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-03-29 to 2019-02-02","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.574Z","intervention":["Device"],"participants":40,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Visual function determined by photoreceptor function over time, measured at 1, 3, 6 and 12 months","Measured at 1, 3, 6 and 12 months: 1. Metrics of photoreceptor function, assessed psychophysically and electrophysiolog…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: ageing, age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87135","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}