{"type":"trials","record":{"id":87136,"source_id":"isrctn","external_id":"ISRCTN47403123","title":"How well does the OriLens (Hubble-type) implant work in improving vision in age-related macular degeneration?","brief_summary":"The aim of this study is to evaluate the efficacy and safety of a new intraocular implantable device (OriLens) to improve vision in participants with severe Age-related Macular Degeneration.","overall_status":"Stopped","phases":[],"study_type":"Interventional","sponsor":"Belfast Health & Social Care Trust","enrollment":132,"countries":["United Kingdom","England","Northern Ireland"],"start_date":"2017-05-23","completion_date":"2019-02-28","last_update_date":"2021-03-01","source_url":"https://www.isrctn.com/ISRCTN47403123","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Stopped. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN47403123; retrieved 2026-09-25","interventions":["Other"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["BCDVA is measured using number of letters improvement on ETDRS Chart at baseline and 12 months.","1. BCDVA is measured using number of letters improvement on ETDRS Chart at one, three and six months 2. BCNVA, reading…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Specialty: Ophthalmology, Primary sub-specialty: Retina (including Diabetes); UKCRC code/ Disease: Eye/ Disorders of ch…","The study is conducted for those who have Age-related Macular Degeneration (AMD) and have had cataract surgery in both…","Uploaded 25/10/2017","Other"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn47403123","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-05-23 to 2019-02-28","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.575Z","intervention":["Other"],"participants":132,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["BCDVA is measured using number of letters improvement on ETDRS Chart at baseline and 12 months.","1. BCDVA is measured using number of letters improvement on ETDRS Chart at one, three and six months 2. BCNVA, reading…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87136","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}