{"type":"trials","record":{"id":87144,"source_id":"isrctn","external_id":"ISRCTN52484108","title":"Assessing visual cortex in candidates for retinal prosthetics","brief_summary":"1. Which measures of brain structure and function best predict successful restoration of vision in patients with macular degeneration implanted with retinal prosthetic devices? 2. Do neural changes occur in brain structure and function when visual inputs are reintroduced after retinal prosthetic implantation?","overall_status":"Completed","phases":[],"study_type":"Observational","sponsor":"University of York","enrollment":5,"countries":["United Kingdom","England"],"start_date":"2015-02-23","completion_date":"2016-02-23","last_update_date":"2018-03-16","source_url":"https://www.isrctn.com/ISRCTN52484108","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN52484108; retrieved 2026-09-25","interventions":["Device"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["The purpose of this study is the feasibility for conducting a larger study in the future. To determine this, the follow…","Secondary outcome measures will be the scientific assessment of neural characteristics of visual cortex within each par…"],"design_description":"Observational","source_has_results":false},"controlled_terms":["Age-related macular degeneration (AMD)","The purpose of the pilot study is to develop quantitative methods to assess brain structure and function in participant…","Device"],"relevance_confidence":60,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn52484108","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-02-23 to 2016-02-23","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.579Z","intervention":["Device"],"participants":5,"study_design":"Observational","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The purpose of this study is the feasibility for conducting a larger study in the future. To determine this, the follow…","Secondary outcome measures will be the scientific assessment of neural characteristics of visual cortex within each par…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as Observational."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87144","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}