{"type":"trials","record":{"id":87146,"source_id":"isrctn","external_id":"ISRCTN58955026","title":"Treating neovascular age-related macular degeneration with aflibercept","brief_summary":"The aim of this study is to compare standard care with an individualised treat and extend regimen of aflibercept in the treatment of neovascular age-related macular degeneration.","overall_status":"Completed","phases":["Not Applicable"],"study_type":"Interventional","sponsor":"York Hospital","enrollment":40,"countries":["United Kingdom","England"],"start_date":"2015-12-01","completion_date":"2021-02-26","last_update_date":"2022-03-02","source_url":"https://www.isrctn.com/ISRCTN58955026","editorial_summary":"A registered Not Applicable study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN58955026; retrieved 2026-09-25","interventions":["Aflibercept","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["To evaluate the feasibility aspects of the study under these headings i.e. process, resources, management and scientifi…","Not provided at time of registration."],"design_description":"Interventional","source_has_results":true},"controlled_terms":["Neovascular age-related macular degeneration","Participants are randomly allocated to one of two groups. Both groups will receive intravitreal injections of afliberce…","Aflibercept","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn58955026","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-12-01 to 2021-02-26","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.580Z","intervention":["Aflibercept","Drug"],"participants":40,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Not Applicable","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["To evaluate the feasibility aspects of the study under these headings i.e. process, resources, management and scientifi…","Not provided at time of registration."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87146","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}