{"type":"trials","record":{"id":87157,"source_id":"isrctn","external_id":"ISRCTN82148651","title":"Age-related macular degeneration (AMD) Light trial","brief_summary":"This trial investigates the hypothesis that low level light presented to the eyes at night will slow the progression of early AMD, and reduce re-treatment rate of neovascular AMD.","overall_status":"Completed","phases":["Phase I/II"],"study_type":"Interventional","sponsor":"Cardiff University (UK)","enrollment":100,"countries":["United Kingdom","England"],"start_date":"2014-03-01","completion_date":"2016-06-30","last_update_date":"2019-03-01","source_url":"https://www.isrctn.com/ISRCTN82148651","editorial_summary":"A registered Phase I/II study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN82148651; retrieved 2026-09-25","interventions":["Device"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["There are two co-primary outcome measures for the study - one a structural measure of disease progression based on reti…","1. The change in drusen volume over the 12 month follow-up period. This will be measured at baseline, and at monthly ap…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Age-related Macular Degeneration","Participants randomly allocated to the intervention arm of the study will wear a lightmask each night for 12 months, wh…","results","protocol","Device"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn82148651","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-03-01 to 2016-06-30","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.583Z","intervention":["Device"],"participants":100,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase I/II","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["There are two co-primary outcome measures for the study - one a structural measure of disease progression based on reti…","1. The change in drusen volume over the 12 month follow-up period. This will be measured at baseline, and at monthly ap…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87157","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}