{"type":"trials","record":{"id":87163,"source_id":"isrctn","external_id":"ISRCTN07479761","title":"The effectiveness of community vs. hospital eye service follow-up for patients with neovascular age-related macular degeneration with controlled disease","brief_summary":"Wet AMD is a condition which causes severe sight loss in older people and is treated with drugs that are injected monthly into the eye. When treatment is stopped patients are monitored for relapse, with treatment restarted if needed. Relapse is unpredictable. Until now only intensive regular monthly review to detect recurrence with retreatment when necessary, results in functional outcomes similar to those observed in the pivotal trials. However, regular review in the hospital eye clinic setting , blocks clinic space, uses valuable resources, is expensive and burdensome to the patients and their carers. The proposed study will exploit an existing bank of clinical data, colour fundus and OCT images collected in the course of a large UK trial which will be used to create vignettes consisting of clinical and image information which will be used to compare the performance of participating optometrists with that of HES ophthalmologists with retinal expertise. The question of interest to the NHS is whether community optometrists can be trained to make decisions about the need for retreatment in patients with neovascular age-related macular degeneration (nAMD) whose disease has been rend…","overall_status":"Completed","phases":["Not Applicable"],"study_type":"Interventional","sponsor":"Queen's University Belfast (UK)","enrollment":96,"countries":["United Kingdom","Northern Ireland"],"start_date":"2013-03-01","completion_date":"2014-09-30","last_update_date":"2017-10-20","source_url":"https://www.isrctn.com/ISRCTN07479761","editorial_summary":"A registered Not Applicable study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN07479761; retrieved 2026-09-25","interventions":["Other"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Participant's judgement of the need for retreatment ('Lesion reactivation, referral to hospital' vs. 'Inactive lesion,…","Secondary outcomes are: 1. Frequency of 'critical' errors judged likely to be sight-threatening, i.e. lesions that need…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Wet age-related macular degeneration (AMD)","The intervention of interest is retreatment decision making by community optometrists. The comparator is retreatment de…","results","cost-effectiveness results","Other"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn07479761","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-03-01 to 2014-09-30","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.586Z","intervention":["Other"],"participants":96,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Not Applicable","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Participant's judgement of the need for retreatment ('Lesion reactivation, referral to hospital' vs. 'Inactive lesion,…","Secondary outcomes are: 1. Frequency of 'critical' errors judged likely to be sight-threatening, i.e. lesions that need…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87163","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}