{"type":"trials","record":{"id":87181,"source_id":"isrctn","external_id":"ISRCTN99532788","title":"Effect of trimetazidine MR 35 mg on the emergence of choroidal neovascularisation in age-related macular degeneration","brief_summary":"To demonstrate a difference between trimetazidine 35 mg and placebo on the emergence of choroidal neovascularisation.","overall_status":"Completed","phases":["Not Applicable"],"study_type":"Interventional","sponsor":"Institut de Recherches Internationales Servier (France)","enrollment":1100,"countries":["Belgium","France","Spain"],"start_date":"1999-03-19","completion_date":"2005-10-31","last_update_date":"2018-04-18","source_url":"https://www.isrctn.com/ISRCTN99532788","editorial_summary":"A registered Not Applicable study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Senior","comparator":null,"attribution":"Source: ISRCTN ISRCTN99532788; retrieved 2026-09-25","interventions":["Trimetazidine MR","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Effect on choroidal neovascularisation evaluated each year.","1. Effect of the serous drusen evaluated each year 2. Evaluation of pigment epithelium lesion evaluated each year 3. Cl…"],"design_description":"Interventional","source_has_results":true},"controlled_terms":["Aged-related macular degeneration","Oral administration of trimetazidine 35 mg or placebo during 3 to 5 years.","Trimetazidine MR","Drug"],"relevance_confidence":80,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn99532788","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"1999-03-19 to 2005-10-31","comparator":null,"confidence":"structured-source","population":"All · Senior","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.593Z","intervention":["Trimetazidine MR","Drug"],"participants":1100,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Not Applicable","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Effect on choroidal neovascularisation evaluated each year.","1. Effect of the serous drusen evaluated each year 2. Evaluation of pigment epithelium lesion evaluated each year 3. Cl…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87181","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}