{"type":"trials","record":{"id":87189,"source_id":"isrctn","external_id":"ISRCTN34410935","title":"Combination therapy of Visudyne, Minocycline, Dexamethasone and Ranibizumab (VIMDER) for the treatment of subfoveal choroidal neovascularisation (CNV)","brief_summary":"To assess the safety and effectiveness of the combined therapy of intravitreal ranubizumab/dexamethasone, oral minocycline and verteporfin photodynamic therapy for subfoveal choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD).","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"King's College Hospital NHS Foundation Trust (UK)","enrollment":20,"countries":["United Kingdom","England"],"start_date":"2007-06-01","completion_date":"2008-06-01","last_update_date":"2017-11-13","source_url":"https://www.isrctn.com/ISRCTN34410935","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"All","age_range":"Adult","comparator":null,"attribution":"Source: ISRCTN ISRCTN34410935; retrieved 2026-09-25","interventions":["Verteporfin, anibizumab, dexamethasone, minocycline","Drug"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Evaluate the changes in visual acuity from baseline at 12 months in patients treated with intravitreal ranibizumab in c…","1. Mean change from baseline in best corrected visual acuity (BCVA) at month six 2. Proportion of patients who gain gre…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Age-related macular degeneration","Patients will receive a reduced light dose (25 J/cm^2) verteporfin photodynamic therapy, and an intravitreal injection…","results of pilot study","Verteporfin, anibizumab, dexamethasone, minocycline","Drug"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn34410935","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-06-01 to 2008-06-01","comparator":null,"confidence":"structured-source","population":"All · Adult","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.597Z","intervention":["Verteporfin, anibizumab, dexamethasone, minocycline","Drug"],"participants":20,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Evaluate the changes in visual acuity from baseline at 12 months in patients treated with intravitreal ranibizumab in c…","1. Mean change from baseline in best corrected visual acuity (BCVA) at month six 2. Proportion of patients who gain gre…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87189","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}