{"type":"trials","record":{"id":87202,"source_id":"isrctn","external_id":"ISRCTN64352175","title":"The impact of indocyanine green (ICG) angiography in multiple diagnostic imaging for the management of exudative age-related macular degeneration (ARMD): a single blind prospective randomised controlled trial of fluorescein angiography vs FA & ICG","brief_summary":"Attempt to identify ophthalmic features and positive predictive value for ICG as 'diagnosis and management modifier'. The use of indocyanine gren angiography (ICG) may facilitate the identification of lesions that have been proposed to respond to laser treatment.","overall_status":"Stopped","phases":[],"study_type":"Interventional","sponsor":"Department of Health","enrollment":240,"countries":["United Kingdom","England"],"start_date":"2004-05-24","completion_date":"2006-05-24","last_update_date":"2011-04-07","source_url":"https://www.isrctn.com/ISRCTN64352175","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Stopped. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"Not Specified","age_range":"Not Specified","comparator":null,"attribution":"Source: ISRCTN ISRCTN64352175; retrieved 2026-09-25","interventions":["Other"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["Moderate and severe visual loss defined as loss of three lines or 15 letters (doubling of visual angles) and loss of 6…","1. ICG rates modification of fluorescein based diagnosis and management 2. Specificity and sensitivity of ophthalmic si…"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Eye Diseases: Age-related macular degeneration (ARMD)","Interventions are fluorescein angiography compared with fluorescein angiography and indocyanine green angiography. Adde…","Other"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn64352175","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2004-05-24 to 2006-05-24","comparator":null,"confidence":"structured-source","population":"Not Specified","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.601Z","intervention":["Other"],"participants":240,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Moderate and severe visual loss defined as loss of three lines or 15 letters (doubling of visual angles) and loss of 6…","1. ICG rates modification of fluorescein based diagnosis and management 2. Specificity and sensitivity of ophthalmic si…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: aging, age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87202","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}