{"type":"trials","record":{"id":87208,"source_id":"isrctn","external_id":"ISRCTN78467674","title":"The effect of a lutein based nutritional supplement on non-exudative age-related macular degeneration (AMD): a double-masked randomised controlled trial","brief_summary":"Age-related macular degeneration is the leading cause of blind registration in the developed world. One aetiological hypothesis involves oxidation and the intrinsic vulnerability of the retina to damage via this process. This has prompted interest in the role of antioxidants in the prevention and treatment of this eye disease.","overall_status":"Completed","phases":[],"study_type":"Interventional","sponsor":"Aston University (UK)","enrollment":159,"countries":["United Kingdom","England"],"start_date":"2003-07-01","completion_date":"2005-01-01","last_update_date":"2018-01-11","source_url":"https://www.isrctn.com/ISRCTN78467674","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T03:46:39.792962+00:00","last_seen_at":"2026-09-25T03:46:39.551+00:00","metadata":{"sex":"Not Specified","age_range":"Not Specified","comparator":null,"attribution":"Source: ISRCTN ISRCTN78467674; retrieved 2026-09-25","interventions":["Lutein based nutritional supplement","Supplement"],"reuse_license":"Registry contribution CC BY 4.0; generated metadata CC0","registry_source":"ISRCTN","outcome_measures":["1. Distance and near Visual Acuity (VA) measured using Bailey-Lovie logMAR charts 2. Contrast sensitivity (CS) measured…","Not provided at time of registration"],"design_description":"Interventional","source_has_results":false},"controlled_terms":["Age-related macular degeneration","The study formulation contains: Lutein 10 mg Vitamin C 250 mg Vitamin E 34 mg Vitamin A 750 µg Zinc 10 mg Copper 0.5 mg","results","protocol","Study website","Lutein based nutritional supplement","Supplement"],"relevance_confidence":100,"source_quality_score":98,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T03:46:42.633202+00:00","duplicate_cluster_key":"id:isrctn78467674","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2003-07-01 to 2005-01-01","comparator":null,"confidence":"structured-source","population":"Not Specified","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T03:46:39.603Z","intervention":["Lutein based nutritional supplement","Supplement"],"participants":159,"study_design":"Interventional","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["1. Distance and near Visual Acuity (VA) measured using Bailey-Lovie logMAR charts 2. Contrast sensitivity (CS) measured…","Not provided at time of registration"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as Interventional."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ISRCTN Registry","homepage_url":"https://www.isrctn.com/"}},"canonical_url":"https://www.immortal.life/trials/87208","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}