{"type":"trials","record":{"id":90625,"source_id":"clinicaltrials-gov","external_id":"NCT03534765","title":"Frailty and Sarcopenia Outcomes in Emergency General Surgery","brief_summary":"1. A retrospective scoping cohort review of adult patients undergoing emergency laparotomy/laparoscopy for acute gastrointestinal (GI) pathology who have had a CT scan of the abdomen(+/- pelvis). CT measured sarcopenia would be compared with clinical outcomes, 30-day and 1-year mortality. 2. A prospective observational cohort study and bio-banking exercise of routinely collected clinical data, in a cohort of patient undergoing emergency laparotomy/laparoscopy or conservative treatment for an otherwise operable pathology. An interrogation of CT measured sarcopenia and a validated clinical frailty score would be analysed against clinical outcomes, 30-day and 1-year mortality. The investigators aim to research the association and predictive advantage of combining subjectively measured frailty, objectively measured CT sarcopenia and other risk predicting tools used in every day surgical practice and surgical outcomes (mortality and morbidity) in a cohort of acute surgical patients undergoing surgery or conservative treatment.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Yeovil District Hospital NHS Foundation Trust","enrollment":294,"countries":["United Kingdom"],"start_date":"2018-10-01","completion_date":"2020-08-01","last_update_date":"2019-01-10","source_url":"https://clinicaltrials.gov/study/NCT03534765","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T04:15:35.799123+00:00","last_seen_at":"2026-09-25T04:15:35.417+00:00","metadata":{"sex":"ALL","acronym":"FrOGS","age_range":"18 Years to 100 Years","comparator":null,"organization":"Yeovil District Hospital NHS Foundation Trust","interventions":["CT abdomen +/- pelvis","Edmunton Frailty Score","Emergency laparotomy for general surgical pathology"],"registry_source":"ClinicalTrials.gov","outcome_measures":["30-day mortality — 30 days post surgery","1 year mortality — 1 year post surgery","Length of stay — Reported at 30 days after surgical procedure","Post-operative morbidity — 30 days post surgery","Destination of discharge from hospital — End of initial hospital inpatient care episode. Closes at time of discharge wi…","Hospital readmission — 30 days after discharge","Participant care needs at time of hospital discharge — End of initial hospital inpatient care episode. Closes at time o…"],"design_description":null,"source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","Emergencies","Surgery","Sarcopenia","CT abdomen +/- pelvis","Edmunton Frailty Score","Emergency laparotomy for general surgical pathology"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T04:15:37.666886+00:00","duplicate_cluster_key":"id:nct03534765","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-10-01 to 2020-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:15:35.418Z","intervention":["CT abdomen +/- pelvis","Edmunton Frailty Score","Emergency laparotomy for general surgical pathology"],"participants":294,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["30-day mortality — 30 days post surgery","1 year mortality — 1 year post surgery","Length of stay — Reported at 30 days after surgical procedure","Post-operative morbidity — 30 days post surgery","Destination of discharge from hospital — End of initial hospital inpatient care episode. Closes at time of discharge wi…","Hospital readmission — 30 days after discharge","Participant care needs at time of hospital discharge — End of initial hospital inpatient care episode. Closes at time o…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/90625","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}