{"type":"trials","record":{"id":90685,"source_id":"clinicaltrials-gov","external_id":"NCT01477164","title":"Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults","brief_summary":"Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins). Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people. Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people. Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":72,"countries":["United States"],"start_date":"2011-11-01","completion_date":"2017-03-01","last_update_date":"2017-08-08","source_url":"https://clinicaltrials.gov/study/NCT01477164","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T04:15:35.799123+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 80 Years","comparator":"Combined","organization":"Mayo Clinic","interventions":["High intensity aerobic exercise","Resistance exercise training","Combined"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Skeletal muscle protein synthesis rate — Approximately 14 weeks for the endurance or resistance training groups and app…"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Sarcopenia","High intensity aerobic exercise","Resistance exercise training","Combined"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct01477164","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-11-01 to 2017-03-01","comparator":"Combined","confidence":"structured-source","population":"ALL · 18 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.570Z","intervention":["High intensity aerobic exercise","Resistance exercise training","Combined"],"participants":72,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Skeletal muscle protein synthesis rate — Approximately 14 weeks for the endurance or resistance training groups and app…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/90685","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}