{"type":"trials","record":{"id":90708,"source_id":"clinicaltrials-gov","external_id":"NCT00690534","title":"Insulin and Sarcopenia in the Elderly","brief_summary":"Muscle loss with aging is a significant contributor to disability in older people. Our general hypothesis is that loss of muscle with aging, known as sarcopenia, may be due to inability of muscle to grow in response to insulin. Our goal is to determine the mechanisms underlying this age-related insulin resistance of muscle proteins, which will allow us to define in the future specific interventions to target this defect and provide the scientific basis for the prevention and treatment of sarcopenia.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"The University of Texas Medical Branch, Galveston","enrollment":88,"countries":["United States"],"start_date":"2005-09-01","completion_date":"2012-08-01","last_update_date":"2016-12-12","source_url":"https://clinicaltrials.gov/study/NCT00690534","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T04:15:35.799123+00:00","last_seen_at":"2026-09-25T04:15:35.417+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 85 Years","comparator":"CMAY; CSNP; CMealO; MealY","organization":"The University of Texas Medical Branch, Galveston","interventions":["Insulin Regular","L-NMMA","Sodium Nitroprusside","mixed meal"],"registry_source":"ClinicalTrials.gov","outcome_measures":["muscle protein synthesis — 5 and 8 hours","blood flow — 5 and 8 hours"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Sarcopenia","Insulin Regular","L-NMMA","Sodium Nitroprusside","mixed meal"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T04:15:37.666886+00:00","duplicate_cluster_key":"id:nct00690534","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2005-09-01 to 2012-08-01","comparator":"CMAY; CSNP; CMealO; MealY","confidence":"structured-source","population":"ALL · 18 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T04:15:35.437Z","intervention":["Insulin Regular","L-NMMA","Sodium Nitroprusside","mixed meal"],"participants":88,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["muscle protein synthesis — 5 and 8 hours","blood flow — 5 and 8 hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/90708","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}