{"type":"trials","record":{"id":91,"source_id":"clinicaltrials-gov","external_id":"NCT02604563","title":"Aging, Geriatric Syndromes and Clonal Hematopoiesis","brief_summary":"In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Washington University School of Medicine","enrollment":2000,"countries":["United States"],"start_date":"2016-03-10","completion_date":"2030-04-30","last_update_date":"2026-07-13","source_url":"https://clinicaltrials.gov/study/NCT02604563","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:59.105435+00:00","last_seen_at":"2026-09-25T06:15:18.072+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Washington University School of Medicine","interventions":["Cognitive Assessment","Activities of Daily Living Questionnaire","Instrumental Activities of Daily Living, subscale of the OARS","Karnofsky Self-reported Performance Rating Scale","Number of Falls","Physical Health Section, subscale of the OARS","MOS Social Activity Survey","Unintentional Weight Loss","Peripheral Blood Draw","Buccal Swab","Heart Health and Smoking History from BRFSS questionnaire","Gait Speed","Grip Strength","Height and Weight measurements","Blood pressure measurement","Optional bone marrow biopsy","Blood draw for trauma measurements","Femur head donation","Knee bone fragments","Bone marrow aspirate"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Background mutation rate in hematopoietic stem cells from older adults regardless of a prior cancer diagnosis as measur…","Presence or absence of geriatric syndromes as measured by hematopoietic stem cell mutations — Estimated to be 10 years","Determine the natural history of mutations in older adults with clonal hematopoiesis as measured by risk to develop blo…","Presence or absence of cardiovascular disease as measured by hematopoietic stem call mutations — Estimated to be 10 yea…","Determine whether expansion of clonal hematopoiesis (CH) occurs following acute trauma — Estimated to be 10 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Geriatrics","Aged","Geriatric Syndromes","Cardiovascular Diseases","Cognitive Assessment","Activities of Daily Living Questionnaire","Instrumental Activities of Daily Living, subscale of the OARS","Karnofsky Self-reported Performance Rating Scale","Number of Falls","Physical Health Section, subscale of the OARS","MOS Social Activity Survey","Unintentional Weight Loss","Peripheral Blood Draw","Buccal Swab","Heart Health and Smoking History from BRFSS questionnaire","Gait Speed","Grip Strength","Height and Weight measurements","Blood pressure measurement","Optional bone marrow biopsy","Blood draw for trauma measurements","Femur head donation","Knee bone fragments","Bone marrow aspirate"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: clonal hematopoiesis.","quality_checked_at":"2026-09-25T06:15:18.821558+00:00","duplicate_cluster_key":"id:nct02604563","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-03-10 to 2030-04-30","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:18.078Z","intervention":["Cognitive Assessment","Activities of Daily Living Questionnaire","Instrumental Activities of Daily Living, subscale of the OARS","Karnofsky Self-reported Performance Rating Scale","Number of Falls","Physical Health Section, subscale of the OARS","MOS Social Activity Survey","Unintentional Weight Loss","Peripheral Blood Draw","Buccal Swab","Heart Health and Smoking History from BRFSS questionnaire","Gait Speed","Grip Strength","Height and Weight measurements","Blood pressure measurement","Optional bone marrow biopsy","Blood draw for trauma measurements","Femur head donation","Knee bone fragments","Bone marrow aspirate"],"participants":2000,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Background mutation rate in hematopoietic stem cells from older adults regardless of a prior cancer diagnosis as measur…","Presence or absence of geriatric syndromes as measured by hematopoietic stem cell mutations — Estimated to be 10 years","Determine the natural history of mutations in older adults with clonal hematopoiesis as measured by risk to develop blo…","Presence or absence of cardiovascular disease as measured by hematopoietic stem call mutations — Estimated to be 10 yea…","Determine whether expansion of clonal hematopoiesis (CH) occurs following acute trauma — Estimated to be 10 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"clonal-hematopoiesis","is_published":true,"match_reasons":["Title contains controlled term: clonal hematopoiesis.","Title supplies longevity context: aging, geriatric.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Clonal haematopoiesis","slug":"clonal-hematopoiesis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/91","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}